Evidence map›Paper›PMID 32020294›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020

Effects of enhanced depth imaging and en face averaging on optical coherence tomography angiography image quantification.

Keke Liu, Nihaal Mehta, A Yasin Alibhai, Malvika Arya, Osama Sorour, Akihiro Ishibazawa, Iksoo Byon, Caroline R Baumal, Andre J Witkin, Jay S Duker and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Keke LiuNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Nihaal MehtaNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
A Yasin AlibhaiNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Malvika AryaNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Osama SorourNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Akihiro IshibazawaNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Iksoo ByonDoheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.
Caroline R BaumalNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Andre J WitkinNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
Jay S DukerNew England Eye Center, Tufts Medical Center, Boston, MA, USA.
SriniVas R SaddaDoheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.
Nadia K WaheedNew England Eye Center, Tufts Medical Center, Boston, MA, USA. nwaheed@tuftsmedicalcenter.org.ORCID http://orcid.org/0000-0002-8229-7519
Tufts Medical Center · USUniversity of California, Los Angeles · USUniversity of Hawaiʻi at Mānoa · US

Funding

Johns Hopkins and Hanoi School of Public Health Trauma and Injury Research ProgramD43TW010473 · FIC · JOHNS HOPKINS UNIVERSITY · PI BACHANI, ABDULGAFOOR M., HYDER, ADNAN A · 2016 to 2020
$1.3M
Air Force Office of Scientific Research FA9550-15-1-0473Beckman-Argyros Award in Vision Research n/aChampalimaud Vision Award n/aMacula Vision Research Foundation n/aMassachusetts Lions Eye Research Fund n/aNIH HHS 5-R01-EY011289-31
6 · The paper itself

Abstract

purposeTo examine the effects of enhanced depth imaging (EDI) and en face averaging on global vascular measurements of optical coherence tomography angiography (OCTA) images.

methodsAll eyes were imaged with 3 mm × 3 mm fields centered at the fovea using the Carl Zeiss Cirrus 5000 spectral-domain OCTA, with and without EDI, and the Zeiss PLEX Elite 9000 swept-source OCTA. Vessel area density (VAD), vessel length (VL), and vessel diameter index (VDI) were calculated for the superficial capillary plexus (SCP) en face angiograms. For the choriocapillaris (CC), VAD and the number, total area, and average size of flow voids were calculated. These metrics were compared between SD- and SS-OCTA images, with and without en face averaging and EDI.

resultsBoth averaging and EDI had a significant effect on quantitative metrics. EDI images trended toward a decrease in SCP VAD. In the CC, EDI decreased average flow void size. Averaging increased CC VAD while decreasing number of flow voids, total flow void area, and average flow void size. With both averaging and EDI, SD-OCTA was not able to visualize as many CC flow voids, particularly of a smaller size, compared with SS-OCTA.

conclusionsAveraging and EDI affect quantitative metrics from SCP and CC OCTA images. EDI resulted in a trend toward decreased VAD in SCP images. Averaging had a major effect on CC imaging. Even with the combination of EDI and en face averaging, SD-OCTA images do not appear to approximate SS-OCTA images in terms of quantitative metrics. This has implications for clinical and research use of SD-OCTA for retinal imaging.

Indexed as

Fluorescein AngiographyTomography, Optical CoherenceAdultChoroidCiliary ArteriesFemaleHealthy VolunteersHumansImage EnhancementMaleProspective StudiesVeinsYoung AdultEnhanced depth imagingOptical coherence tomography angiographyRetinal imaging

Identifiers

PMID32020294
OpenAlexW3004892448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.