Evidence map›Paper›PMID 32020086›Full record

ArticleNature medicine2020

Resistance looms for KRAS

Aaron N Hata, Alice T Shaw

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Covalent inhibitor targets KRasGenes & diseases · 2023
    Review
  10. TargetingGastroenterology report · 2023
    Review
  11. Article
  12. Article
  13. Drugging KRAS: current perspectives and state-of-art review.Journal of hematology & oncology · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Direct TargetingCancers · 2022
    Review
  19. Article
  20. The path to the clinic: a comprehensive review on direct KRASJournal of experimental & clinical cancer research : CR · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Aaron N HataMassachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA. ahata@mgh.harvard.edu.
Alice T ShawNovartis Institutes of Biomedical Research, Cambridge, MA, USA. ashaw1@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsLung NeoplasmsHumansProto-Oncogene Proteins p21(ras)Antineoplastic AgentsKRAS protein, humanProto-Oncogene Proteins p21(ras)

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.