ArticleScientific reports2020
Methylene blue administration in patients with refractory distributive shock - a retrospective study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Efficacy and safety of methylene blue in patients with vasodilatory shock: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- The Effect of Methylene Blue on Sublingual Microcirculation in Patients with Septic Shock: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- The Effectiveness of Methylene Blue in Adult Shock: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Vasoactive-Inotropic Score Reduction Rate Is Highly Associated With Prognosis for Critically Ill Patients With Cardiogenic Shock: Insights From the Real-World Dynamic Data.Cardiovascular therapeutics · 2026Observational
- Article
- The current use of vasoactive agents in cardiogenic shock related to myocardial infarction and acute decompensated heart failure.American heart journal plus : cardiology research and practice · 2025Article
- Predicting responsiveness to fixed-dose methylene blue in adult patients with septic shock using interpretable machine learning: a retrospective study.Scientific reports · 2025Article
- Efficacy and safety of phospholipid nanoparticles (VBI-S) in reversing intractable hypotension in patients with septic shock: a multicentre, open-label, repeated measures, phase 2a clinical pilot trial.EClinicalMedicine · 2024Article
- State of Shock: Contemporary Vasopressor and Inotrope Use in Cardiogenic Shock.Journal of the American Heart Association · 2023Review
- Methylene Blue in Refractory Shock.Cureus · 2022Article
- Article
- Methylene blue for vasodilatory shock in the intensive care unit: a retrospective, observational study.BMC anesthesiology · 2022Observational
- Developing a COVID-19 WHO Clinical Progression Scale inpatient database from electronic health record data.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Methylene blue for the treatment of refractory septic shock secondary to listeriosis in a paediatric patient.BMJ case reports · 2022Article
- Epineural Methylene Blue Injection May Aid Localization of Digital Nerves in Dupuytren's Surgery.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2022Article
- Methylene blue dosing strategies in critically ill adults with shock-A retrospective cohort study.Frontiers in medicine · 2022Article
- Mechanical strength and hydrostatic testing of VIVO adhesive in sutureless microsurgical anastomoses: an ex vivo study.Scientific reports · 2021Article
- Vasopressor-Sparing Action of Methylene Blue in Severe Sepsis and Shock: A Narrative Review.Advances in therapy · 2020Review
- Methylene blue as an adjuvant during cardiopulmonary resuscitation: an experimental study in rats.Brazilian journal of anesthesiology (Elsevier)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemodynamic effectiveness of methylene blue (MB) was tested in patients with refractory distributive shock. A retrospective analysis of 20 critically-ill patients who developed refractory shock was performed. Patients were divided into two study groups as responders with positive hemodynamic response to MB administration (defined as 10% decrease of norepinephrine dose) and non-responders. Hemodynamic, outcome data and baseline tissue hypoxia-related parameters including ratio of central venous-to-arterial carbon dioxide tension to arterio-venous oxygen content (P(v-a)CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.