ArticleScientific reports2020
Streptomyces sp. VN1, a producer of diverse metabolites including non-natural furan-type anticancer compound.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
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- Biological activity of secondary metabolites of actinomycetes and their potential sources as antineoplastic drugs: a review.Frontiers in microbiology · 2025Review
- EditingEngineering in life sciences · 2024Article
- A Genomics-Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in the Potential Novel StrainMicroorganisms · 2024Article
- Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents.Cancer gene therapy · 2024Review
- Marine-DerivedMicroorganisms · 2023Article
- Bacterial Community Composition and Isolation of Actinobacteria from the Soil of Flaming Mountain in Xinjiang, China.Microorganisms · 2023Article
- Antifungal Activities of Compounds Produced by Newly IsolatedAntibiotics (Basel, Switzerland) · 2023Article
- Investigation of diverse biosynthetic secondary metabolites gene clusters using genome mining of indigenousIranian journal of microbiology · 2022Article
- Undescribed Metabolites from an ActinobacteriaMolecules (Basel, Switzerland) · 2022Article
- Bioactive Microbial Metabolites in Cancer Therapeutics: Mining, Repurposing, and Their Molecular Targets.Current microbiology · 2022Review
- Secondary Metabolites with Anti-Inflammatory Activities from an Actinobacteria Herbidospora daliensisMolecules (Basel, Switzerland) · 2022Article
- Secondary Metabolites from Marine-Derived Fungi and Actinobacteria as Potential Sources of Novel Colorectal Cancer Drugs.Marine drugs · 2022Review
- Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review.Frontiers in pharmacology · 2022Review
- Lobophorin Producing EndophyticFrontiers in microbiology · 2022Article
- Molecular and Structural Parallels between Gluten Pathogenic Peptides and Bacterial-Derived Proteins by Bioinformatics Analysis.International journal of molecular sciences · 2021Article
- Biosynthetic Potential ofAntibiotics (Basel, Switzerland) · 2021Article
- Antimicrobial resistance in biofilms: Exploring marine actinobacteria as a potential source of antibiotics and biofilm inhibitors.Biotechnology reports (Amsterdam, Netherlands) · 2021Review
- Draft Genome Sequence ofMicrobiology resource announcements · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces sp. VN1 was isolated from the coastal region of Phu Yen Province (central Viet Nam). Morphological, physiological, and whole genome phylogenetic analyses suggested that strain Streptomyces sp. VN1 belonged to genus Streptomyces. Whole genome sequencing analysis showed its genome was 8,341,703 base pairs in length with GC content of 72.5%. Diverse metabolites, including cinnamamide, spirotetronate antibiotic lobophorin A, diketopiperazines cyclo-L-proline-L-tyrosine, and a unique furan-type compound were isolated from Streptomyces sp. VN1. Structures of these compounds were studied by HR-Q-TOF ESI/MS/MS and 2D NMR analyses. Bioassay-guided purification yielded a furan-type compound which exhibited in vitro anticancer activity against AGS, HCT116, A375M, U87MG, and A549 cell lines with IC
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