ArticleNature communications2020
Direct electrical stimulation of the premotor cortex shuts down awareness of voluntary actions.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A probabilistic map of motor and cognitive functions: a meta-analysis of 4325 stimulation sites.Brain structure & function · 2025Pooled it
- An update on tests used for intraoperative monitoring of cognition during awake craniotomy.Acta neurochirurgica · 2024Pooled it
- Object-oriented hand dexterity and grasping abilities, from the animal quarters to the neurosurgical OR: a systematic review of the underlying neural correlates in non-human, human primate and recent findings in awake brain surgery.Frontiers in integrative neuroscience · 2024Pooled it
- Neural bases of the bodily self as revealed by electrical brain stimulation: A systematic review.Human brain mapping · 2023Pooled it
- Glioma surgery with awake language mapping versus generalized anesthesia: a systematic review.Neurosurgical review · 2021Pooled it
- Trial
- Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microstructure and gene expression influence gyrification in amyotrophic lateral sclerosis.Brain communications · 2026Article
- The frequency-dependent effects of primary hand motor cortex stimulation on volitional finger movement.Clinical neurophysiology practice · 2026Article
- Biocompatible PVDF Nanofibers with Embedded Magnetite Nanodiscs Enable Wireless Magnetoelectric Stimulation in Premotor Cortex.Advanced healthcare materials · 2025Article
- Pre-movement sensorimotor oscillations shape the sense of agency by gating cortical connectivity.Nature communications · 2025Article
- From non-human to human primates: a translational approach to enhancing resection, safety, and indications in glioma surgery while preserving sensorimotor abilities.Frontiers in integrative neuroscience · 2025Review
- The role of dorsal premotor cortex in joint action inhibition.Scientific reports · 2024Article
- Catatonia: A deep dive into its unfathomable depths.World journal of psychiatry · 2024Article
- The surgical management of diffuse gliomas: Current state of neurosurgical management and future directions.Neuro-oncology · 2023Article
- Modulation of Motor Awareness: A Transcranial Magnetic Stimulation Study in the Healthy Brain.Brain sciences · 2023Article
- Association of Cortical Gyrification With Imaging and Serum Biomarkers in Patients With Parkinson Disease.Neurology · 2023Article
- Beyond Avoiding Hemiplegia after Glioma Surgery: The Need to Map Complex Movement in Awake Patient to Preserve Conation.Cancers · 2023Review
- Premotor cortex is hypoactive during sustained vowel production in individuals with Parkinson's disease and hypophonia.Frontiers in human neuroscience · 2023Article
- Cortical and subcortical morphological alterations in motor subtypes of Parkinson's disease.NPJ Parkinson's disease · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A challenge for neuroscience is to understand the conscious and unconscious processes underlying construction of willed actions. We investigated the neural substrate of human motor awareness during awake brain surgery. In a first experiment, awake patients performed a voluntary hand motor task and verbally monitored their real-time performance, while different brain areas were transiently impaired by direct electrical stimulation (DES). In a second experiment, awake patients retrospectively reported their motor performance after DES. Based on anatomo-clinical evidence from motor awareness disorders following brain damage, the premotor cortex (PMC) was selected as a target area and the primary somatosensory cortex (S1) as a control area. In both experiments, DES on both PMC and S1 interrupted movement execution, but only DES on PMC dramatically altered the patients' motor awareness, making them unconscious of the motor arrest. These findings endorse PMC as a crucial hub in the anatomo-functional network of human motor awareness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.