ArticleNature communications2020
Multicomponent molecular memory.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
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- Microwave-Intensified Hofmann Carbylamine Reaction Enabled by SpanMolecules (Basel, Switzerland) · 2026Article
- Storing Data With Propargylic Amines Using Thin-Layer Chromatography for the Data Retrieval.ChemPlusChem · 2026Article
- DNA Helix Bundle-Encoded Multi-Bit Information Readout by Sapphire-Supported Nanopores.Advanced functional materials · 2026Article
- Liquid-in-Liquid Prints: High-Density Biochemically Encoded Information Preserved in Microdroplet Arrays.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Magnetic Blocking in Fluoflavine Radical-Bridged Dilanthanide Complexes.Journal of the American Chemical Society · 2025Article
- High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-Specific Protease mUSP18.Angewandte Chemie (International ed. in English) · 2025Article
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- De novo non-canonical nanopore basecalling enables private communication using heavily-modified DNA data at single-molecule level.Nature communications · 2025Article
- Super-multiplexed imaging and coding in the range of radio frequency.Nature communications · 2025Article
- Is stochastic thermodynamics the key to understanding the energy costs of computation?Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Combinatorial discovery of antibacterialsChemical science · 2024Article
- Structures, fundamental properties, and potential applications of low-dimensional CScience and technology of advanced materials · 2024Review
- How Important is the Metal-free Catalytic Knoevenagel Reaction in Medicinal Chemistry? An Updated Review.Current medicinal chemistry · 2024Review
- Molecular data storage using direct analysis in real time (DART) ionization mass spectrometry for decoding.Scientific reports · 2023Article
- The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems.ACS central science · 2023Article
- Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction?The Journal of organic chemistry · 2023Review
- Digital circuits and neural networks based on acid-base chemistry implemented by robotic fluid handling.Nature communications · 2023Article
- Molecular Encryption and Steganography Using Mixtures of Simultaneously Sequenced, Sequence-Defined Oligourethanes.ACS central science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multicomponent reactions enable the synthesis of large molecular libraries from relatively few inputs. This scalability has led to the broad adoption of these reactions by the pharmaceutical industry. Here, we employ the four-component Ugi reaction to demonstrate that multicomponent reactions can provide a basis for large-scale molecular data storage. Using this combinatorial chemistry we encode more than 1.8 million bits of art historical images, including a Cubist drawing by Picasso. Digital data is written using robotically synthesized libraries of Ugi products, and the files are read back using mass spectrometry. We combine sparse mixture mapping with supervised learning to achieve bit error rates as low as 0.11% for single reads, without library purification. In addition to improved scaling of non-biological molecular data storage, these demonstrations offer an information-centric perspective on the high-throughput synthesis and screening of small-molecule libraries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.