ArticleNature communications2020
Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
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- Transcriptomic Correlates of State Modulation in GABAergic Interneurons: A Cross-Species Analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Clustered synapses develop in distinct dendritic domains in visual cortex before eye opening.eLife · 2024Article
- Comprehensive software suite for functional analysis and synaptic input mapping of dendritic spines imagedNeurophotonics · 2024Article
- A neurophysiological basis for aperiodic EEG and the background spectral trend.Nature communications · 2024Article
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- Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023Review
- Genetic Approaches for Neural Circuits Dissection in Non-human Primates.Neuroscience bulletin · 2023Review
- Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo.Journal of neurochemistry · 2023Review
- Object Boundary Detection in Natural Images May Depend on "Incitatory" Cell-Cell Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2022Review
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- Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators.Nature reviews. Neuroscience · 2022Review
- Classical-Contextual Interactions in V1 May Rely on Dendritic Computations.Neuroscience · 2022Article
- Perceptual hue, lightness, and chroma are represented in a multidimensional functional anatomical map in macaque V1.Progress in neurobiology · 2022Article
- Spatially distributed computation in cortical circuits.Science advances · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integration of synaptic inputs onto dendrites provides the basis for neuronal computation. Whereas recent studies have begun to outline the spatial organization of synaptic inputs on individual neurons, the underlying principles related to the specific neural functions are not well understood. Here we perform two-photon dendritic imaging with a genetically-encoded glutamate sensor in awake monkeys, and map the excitatory synaptic inputs on dendrites of individual V1 superficial layer neurons with high spatial and temporal resolution. We find a functional integration and trade-off between orientation-selective and color-selective inputs in basal dendrites of individual V1 neurons. Synaptic inputs on dendrites are spatially clustered by stimulus feature, but functionally scattered in multidimensional feature space, providing a potential substrate of local feature integration on dendritic branches. Furthermore, apical dendrite inputs have larger receptive fields and longer response latencies than basal dendrite inputs, suggesting a dominant role for apical dendrites in integrating feedback in visual information processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.