ArticleNature communications2020
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.
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In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 274 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 1 pooled it
18.6field-weighted citation impact, top 1% of its field
What it found
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Who cites it
274 citing papers in PubMed, 1 synthesis or guideline pooled it, 425 citations in OpenAlex.
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- Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.Bioactive materials · 2027Review
- The potential of plant-derived exosome-like nanovesicles fromFuture science OA · 2026Article
- A closed-loop myocardial infarction theranostic platform activated by macrophage-derived nitric oxide and acidic microenvironment.Bioactive materials · 2026Article
- Dynamic metabolic programming of monocyte-derived cells defines immunity in CNS disease.Brain : a journal of neurology · 2026Review
- Nitric oxide dependent metabolic and genetic dysregulation in metastatic triple-negative breast cancer.The Journal of biological chemistry · 2026Article
- Macrophage immunometabolic reprogramming in inflammatory repair failure in osteonecrosis of the femoral head.Journal of orthopaedic translation · 2026Review
- Narrative Review on Therapies That Influence Inflammatory Responses During Extremely Premature Perinatal Respiratory Transition.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Nitric oxide-driven Warburg reprogramming at the NOS2-COX2 axis: An integrative engine of cancer hallmarks.Redox biology · 2026Review
- NADPH oxidases in immunometabolism and disease pathology: mechanistic networks, pollutant triggers, and therapeutic frontiers.Cellular & molecular immunology · 2026Review
- Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response.Science advances · 2026Article
- Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026Review
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- Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review).International journal of molecular medicine · 2026Review
- Metal-drug coordinated nanozymes for ROS scavenging and Kupffer cell polarization to alleviate drug-induced liver injury.Acta pharmaceutica Sinica. B · 2026Article
- Vitronectin metabolically programs profibrotic macrophages in 3D cultures and idiopathic pulmonary fibrosis.Science advances · 2026Article
- Immunometabolic reprogramming of macrophages by miR-423-5p-enriched small extracellular vesicles delivered via glucose/ROS-responsive hydrogel for diabetic wound healing.Journal of nanobiotechnology · 2026Article
- β-catenin-driven innate and metabolic reprograming in macrophages fuel T-cell-dependent inflammation in Toxoplasma gondii infection: implications for therapeutic intervention.Cell death & disease · 2026Article
- Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti-Tumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1.Redox biology · 2026Article
214 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
Erika M PalmieriLeukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.
Marieli Gonzalez-CottoLeukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.
Walter A BaselerLeukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.
Luke C DaviesLeukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.
Bart GhesquièreMetabolomics Expertise Center, Vesalius Research Center, VIB, 3000, Leuven, Belgium.
Nunziata MaioMolecular Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Christopher M RiceLeukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA.
Tracey A RouaultMolecular Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0062-0245
Teresa CasselDepartment of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.
Richard M HigashiDepartment of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.
Andrew N LaneDepartment of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0003-1121-5106
Teresa W-M FanDepartment of Toxicology and Cancer Biology and Markey Cancer Center and Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0002-7292-8938
David A WinkChemical and Molecular Inflammation Section, Cancer and Inflammation Program, National Cancer Institute, Frederick, MD, USA.
Daniel W McVicarLeukocyte Signaling Section, Cancer & Inflammation Program, National Cancer Institute, Frederick, MD, USA. mcvicard@mail.nih.gov.ORCID http://orcid.org/0000-0002-1112-5111
National Cancer Institute · USUniversity of Kentucky · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Bristol · GBVIB-KU Leuven Center for Cancer Biology · BE
Funding
University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3MSignal Transduction of Paired Inhibitory Receptors of NK Cells and MacrophagesZIABC010300 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MCVICAR, DANIEL W. · 2009 to 2025
$24.6MSAMPLE COREU24DK097215 · NIDDK · UNIVERSITY OF KENTUCKY · PI FAN, TERESA WHEI-MEI, HIGASHI, RICHARD M · 2013 to 2017
$8.7MNitric Oxide as a Modifier of Oxidative StressZIASC007281 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI WINK, DAVID · 2009 to 2025
$8.1MCHemical Biology of Nitroxyl (HNO)ZIABC011190 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINK, DAVID · 2009 to 2025
$2.9MNCI NIH HHS P30 CA177558NIDDK NIH HHS U24 DK097215Wellcome Trust
Abstract
Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) produced by murine macrophages is responsible for TCA cycle alterations and citrate accumulation associated with polarization.
Indexed as
Aconitate HydrataseAnimalsCitric AcidCitric Acid CycleElectron Transport Chain Complex ProteinsHumansHypoxia-Inducible Factor 1, alpha SubunitInflammationMacrophagesMiceMice, Inbred C57BLMice, KnockoutMitochondriaNitric OxideNitric Oxide Synthase Type IIPyruvate Dehydrogenase Acetyl-Transferring KinaseAconitate HydrataseCitric AcidElectron Transport Chain Complex ProteinsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitNitric OxideNitric Oxide Synthase Type IINos2 protein, mousePdk1 protein, mousePyruvate Dehydrogenase Acetyl-Transferring KinasePyruvic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.