Evidence map›Paper›PMID 32019801›Full record

ArticlemBio2020

Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway.

James I P Stewart, Vinicius M Fava, Joshua D Kerkaert, Adithya S Subramanian, Fabrice N Gravelat, Melanie Lehoux, P Lynne Howell, Robert A Cramer, Donald C Sheppard

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  6. Is Cryptococcus neoformans a pleomorphic fungus?Current opinion in microbiology · 2024
    Review
  7. Article
  8. The forced activation of asexual conidiation inSynthetic and systems biotechnology · 2024
    Article
  9. Potential Antifungal Targets forInternational journal of molecular sciences · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Journal of immunology research · 2021
    Article
  19. Article
  20. Precise Expression ofmSphere · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

James I P StewartDepartment of Experimental Medicine, McGill University, Glen Site, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0001-8516-7325
Vinicius M FavaInfectious Diseases and Immunity in Global Health Program, Glen Site, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0001-9142-1713
Joshua D KerkaertDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0001-6869-7404
Adithya S SubramanianProgram in Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Fabrice N GravelatInfectious Diseases and Immunity in Global Health Program, Glen Site, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0003-2416-9380
Melanie LehouxInfectious Diseases and Immunity in Global Health Program, Glen Site, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
P Lynne HowellProgram in Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-2776-062X
Robert A CramerDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0001-5503-5006
Donald C SheppardDepartment of Experimental Medicine, McGill University, Glen Site, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada don.sheppard@mcgill.ca.ORCID 0000-0001-8877-880X
McGill University Health Centre · CADartmouth College · USUniversity of Toronto · CA

Funding

HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
Evolution of Aspergillus fumigatus virulenceR01AI130128 · NIAID · DARTMOUTH COLLEGE · PI Robert Andrew Cramer · 2017 to 2026
$4.5M
NIAID NIH HHS R01 AI130128NIAID NIH HHS T32 AI007519
6 · The paper itself

Abstract

Inhalation of conidia of the opportunistic mold

Indexed as

AnimalsAspergillosisAspergillus fumigatusDoxycyclineFemaleFungal ProteinsLarvaMiceMice, Inbred BALB CMothsProof of Concept StudySpores, FungalTranscription FactorsVirulenceVirulence FactorsBrlA protein, Aspergillus fumigatusDoxycyclineFungal ProteinsTranscription FactorsVirulence FactorsAspergillus fumigatusconidiationdrug targetsinducible gene expressionopportunistic pathogenRNA sequencingvirulence

Identifiers

PMID32019801
PMCPMC7002347
OpenAlexW3005048641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.