Evidence map›Paper›PMID 32019591›Full record

ArticleBMC research notes2020

R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability.

S R Jackson, M F D M Costa, C F Pastore, G Zhao, A I Weiner, S Adams, G Palashikar, K Quansah, K Hankenson, D R Herbert and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

S R JacksonDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
M F D M CostaDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
C F PastoreDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
G ZhaoDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
A I WeinerDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
S AdamsDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
G PalashikarDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
K QuansahDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
K HankensonDepartment of Orthopaedic Surgery, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.
D R HerbertDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA.
A E VaughanDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Old Vet 372E, Philadelphia, PA, 19104, USA. andrewva@vet.upenn.edu.ORCID http://orcid.org/0000-0001-5740-643X
University of Pennsylvania · USCalifornia Institute for Regenerative Medicine · USUniversity of Michigan · US

Funding

Trefoil factor proteins regulate inflammation and immunityU01AI125940 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2016 to 2021
$2.8M
Trefoil Factors Regulate Th2 ImmunityR01AI095289 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2011 to 2015
$2.1M
Heterogeneity and Bias of Lineage Negative Progenitors in Lung Epithelial Repair R00HL131817 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VAUGHAN, ANDREW · 2017 to 2019
$722k
NHLBI NIH HHS R00 HL131817NIAID NIH HHS R01 AI095289NIAID NIH HHS U01 AI125940NIH HHS AI095289NIH HHS R00HL131817NIH HHS U01-AI125940
6 · The paper itself

Abstract

objectiveR-spondin 2 (RSPO2) is required for lung morphogenesis, activates Wnt signaling, and is upregulated in idiopathic lung fibrosis. Our objective was to investigate whether RSPO2 is similarly important in homeostasis of the adult lung. While investigating the characteristics of bronchoalveolar lavage in RSPO2-deficient (RSPO2

resultsQuantitative PCR (qPCR) analysis demonstrated significantly elevated myeloperoxidase (MPO) expression in bronchoalveolar lavage fluid (BALF) cells from RSPO2

Indexed as

AnimalsBronchoalveolar Lavage FluidFemaleGene DeletionMaleMice, Inbred C57BLNeutrophilsPermeabilityPulmonary AlveoliR-SpondinsThrombospondinsRSPO2 protein, mouseR-SpondinsThrombospondinsAlveolar spaceBALFFITC-dextranLung endothelial barrierLung permeabilityNeutrophil migrationR-spondin 2Wnt signaling

Identifiers

PMID32019591
PMCPMC7001225
OpenAlexW3012783020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.