ArticleStem cell research & therapy2020
Cell-free fat extract promotes tissue regeneration in a tissue expansion model.
Article in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- A Dual-Network Injectable Hydrogel Scaffold Integrating Glycyrrhizic Acid and Acellular Fat Extracts for Synergistic Enhancement of Diabetic Wound Healing.ACS polymers Au · 2026Article
- Cell-Free Fat Extract (CEFFE) as a Versatile Cell-Free Biologic for Multitissue Regeneration: From Skin and Bone to Nerve, Reproductive, and Systemic Applications-A Comprehensive Review.BioMed research international · 2026Review
- Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages.Pharmaceutics · 2025Article
- Cell-Free Fat Extract (Ceffe) Combined with GelMA Hydrogel to Improve the Survival Rate of Random Skin Flaps in Mice.ACS biomaterials science & engineering · 2025Article
- Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence.Stem cell research & therapy · 2025Article
- Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects.Cells · 2025Review
- Autologous Cell-Free Fat Extract: A Novel Approach for Infraorbital Rejuvenation-A Pilot Study.Journal of cosmetic dermatology · 2025Article
- Cell-free fat extract improves embryo development and clinical outcomes in older women with previous in-vitro fertilization failure.Reproductive biology and endocrinology : RB&E · 2025Article
- Mechanical force regulates the paracrine functions of ADSCs to assist skin expansion in rats.Stem cell research & therapy · 2024Article
- Cell-free fat extract regulates oxidative stress and alleviates Th2-mediated inflammation in atopic dermatitis.Frontiers in bioengineering and biotechnology · 2024Article
- Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy.Frontiers in cellular neuroscience · 2024Article
- Cell-free fat extract-loaded microneedles attenuate inflammation-induced apoptosis and mitochondrial damage in tendinopathy.Materials today. Bio · 2023Article
- Metabolic Mechanisms and Potential Therapeutic Targets for Prevention of Ovarian Aging: Data from Up-to-Date Experimental Studies.International journal of molecular sciences · 2023Review
- Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion.International journal of molecular sciences · 2022Review
- Cell-free fat extract improves ovarian function and fertility in mice with premature ovarian insufficiency.Stem cell research & therapy · 2022Article
- Cell-free fat extract attenuates osteoarthritis via chondrocytes regeneration and macrophages immunomodulation.Stem cell research & therapy · 2022Article
- Advances in wound repair and regeneration: Systematic comparison of cell free fat extract and platelet rich plasma.Frontiers in chemistry · 2022Article
- Cell-free fat extract protects septic lethality via restraining NLRP3 inflammasome activation.American journal of translational research · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTissue expansion techniques play an important role in plastic surgery. How to improve the quality of the expanded skin and shorten the expansion period are still worth investigating. Our previous studies found that a cell-free fat extract (CEFFE) possessed pro-angiogenic and pro-proliferative activities. However, the role of CEFFE on tissue expansion has remained unclear. The purpose of this study was to evaluate the effect of CEFFE on tissue expansion.
methodsA rat tissue expansion model was used. Animals were treated with CEFFE by subcutaneous injection. After 4 weeks of tissue expansion, the skin necrosis and retraction rates were evaluated, the thicknesses of the epidermis and dermis were determined by histological analyses, blood vessel density was measured by anti-CD31 staining, cell proliferation was assessed by proliferating cell nuclear antigen staining, and the expression of specific proteins was evaluated by western blot analyses. In addition, the effects of CEFFE on the proliferation and cell cycle of cultured HaCaT cells were evaluated in vitro.
resultsCEFFE treatment significantly decreased the necrosis rate and retraction of the expanded skin. The thickness of the epidermal and dermal layers was higher in CEFFE-treated compared to untreated skin. The density of blood vessels and cell proliferation in the epidermis of the expanded skin was improved by CEFFE treatment. In addition, CEFFE treatment significantly increased the expression of the vascular endothelial growth factor receptor, epidermal growth factor receptor, collagen type 1, and collagen type 3. CEFFE also increased the proliferation of HaCaT cells in culture.
conclusionsCEFFE improves the quality of the expanded skin by promoting angiogenesis and cell proliferation. It could be potentially used clinically for augmenting tissue expansion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.