Evidence map›Paper›PMID 32019577›Full record

ArticleBMC research notes2020

Stability of neuropsychological test performance in older adults serving as normative controls for a study on postoperative cognitive dysfunction.

Insa Feinkohl, Friedrich Borchers, Sarah Burkhardt, Henning Krampe, Antje Kraft, Saya Speidel, Ilse M J Kant, Simone J T van Montfort, Ellen Aarts, Jochen Kruppa and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02265263 (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02265263 terminatednot on this map

Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog)

TypeobservationalSponsorCharite University, Berlin, GermanyRan2014 to 2019Enrolled1,054ConditionsPostoperative Delirium (POD), Postoperative Cognitive Deficit (POCD)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
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  4. Observational
  5. Review
  6. Observational
  7. Article
  8. Article
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  12. Perioperative Levels of IL8 and IL18, but not IL6, are Associated with Nucleus Basalis Magnocellularis Atrophy Three Months after Surgery.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Article
  13. Article
  14. Article
  15. The Association of Persistent Low Back Pain With Older Adult Falls and Collisions: A Longitudinal Analysis.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2021
    Article
  16. Observational
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Insa FeinkohlMax-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Roessle-Str. 10, 13092, Berlin, Germany. insa.feinkohl@mdc-berlin.de.ORCID http://orcid.org/0000-0002-0307-1862
Friedrich BorchersDepartment of Anesthesiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Sarah BurkhardtFaculty of Psychology, Philipps-Universität Marburg, Marburg, Germany.
Henning KrampeDepartment of Anesthesiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Antje KraftDepartment of Psychiatry, Psychiatric University Hospital St. Hedwig, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Saya SpeidelDepartment of Anesthesiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Ilse M J KantDepartment of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Simone J T van MontfortDepartment of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Ellen AartsDepartment of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jochen KruppaInstitute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Arjen SlooterDepartment of Intensive Care Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Georg WintererPharmaimage Biomarker Solutions GmbH, Berlin, Germany.
Tobias PischonMax-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Roessle-Str. 10, 13092, Berlin, Germany.
Claudia SpiesDepartment of Anesthesiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Funding

Seventh Framework Programme HEALTH-F2-2014-602461
6 · The paper itself

Abstract

objectiveStudies of postoperative cognitive dysfunction (POCD) rely on repeat neuropsychological testing. The stability of the applied instruments, which are affected by natural variability in performance and measurement imprecision, is often unclear. We determined the stability of a neuropsychological test battery using a sample of older adults from the general population. Forty-five participants aged 65 to 89 years performed six computerized and non-computerized neuropsychological tests at baseline and again at 7 day and 3 months follow-up sessions. Mean scores on each test were compared across time points using repeated measures analyses of variance (ANOVA) with pairwise comparison. Two-way mixed effects, absolute agreement analyses of variance intra-class correlation coefficients (ICC) determined test-retest reliability.

resultsAll tests had moderate to excellent test-retest reliability during 7-day (ICC range 0.63 to 0.94; all p < 0.01) and 3-month intervals (ICC range 0.60 to 0.92; all p < 0.01) though confidence intervals of ICC estimates were large throughout. Practice effects apparent at 7 days eased off by 3 months. No substantial differences between computerized and non-computerized tests were observed. We conclude that the present six-test neuropsychological test battery is appropriate for use in POCD research though small sample size of our study needs to be recognized as a limitation. Trial registration ClinicalTrials.gov Identifier NCT02265263 (15th October 2014).

Indexed as

Neuropsychological TestsAgedAged, 80 and overCase-Control StudiesFemaleHumansMalePostoperative Cognitive ComplicationsReproducibility of ResultsCognitive ageingComputerized testingNeuropsychological testingPostoperative cognitive dysfunctionTest–retest reliability

Identifiers

PMID32019577
PMCPMC7001199

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.