Evidence map›Paper›PMID 32019528›Full record

ArticleBMC nephrology2020

Lifetime cost-effectiveness analysis of first-line dialysis modalities for patients with end-stage renal disease under peritoneal dialysis first policy.

Carlos K H Wong, Julie Chen, Samuel K S Fung, Maggie Mok, Yuk Lun Cheng, Irene Kong, Wai Kei Lo, Sing Leung Lui, T M Chan, Cindy L K Lam

Abstract readComparative Study
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Barriers and Opportunities in Access to Peritoneal Dialysis across Veterans Health Administration.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  4. Review
  5. Article
  6. Unveiling Challenges Hindering the Growth of Home Dialysis in Finland: Insights From 40 Years of Experience.Hemodialysis international. International Symposium on Home Hemodialysis · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Tackling Dialysis Burden around the World: A Global Challenge.Kidney diseases (Basel, Switzerland) · 2021
    Article
  15. Article
  16. Chronic kidney failure following lancehead bite envenoming: a clinical report from the Amazon region.The journal of venomous animals and toxins including tropical diseases · 2020
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlos K H WongDepartment of Family Medicine and Primary Care, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Rm 1-01, 1/F, Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Pokfulam, Hong Kong, China. carlosho@hku.hk.ORCID 0000-0002-6895-6071
Julie ChenDepartment of Family Medicine and Primary Care, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Rm 1-01, 1/F, Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Pokfulam, Hong Kong, China.ORCID 0000-0002-7444-6182
Samuel K S FungDepartment of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China.
Maggie MokDivision of Nephrology, Department of Medicine, Tung Wah Hospital, Hong Kong, China.
Yuk Lun ChengDepartment of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China.
Irene KongDepartment of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China.
Wai Kei LoDivision of Nephrology, Department of Medicine, Tung Wah Hospital, Hong Kong, China.
Sing Leung LuiDivision of Nephrology, Department of Medicine, Tung Wah Hospital, Hong Kong, China.
T M ChanDivision of Nephrology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.ORCID 0000-0002-3495-4051
Cindy L K LamDepartment of Family Medicine and Primary Care, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Rm 1-01, 1/F, Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Pokfulam, Hong Kong, China.ORCID 0000-0001-7536-8481

Funding

Health and Medical Research Fund 13142451
6 · The paper itself

Abstract

backgroundThis study aimed to determine the lifetime cost-effectiveness of first-line dialysis modalities for end-stage renal disease (ESRD) patients under the "Peritoneal Dialysis First" policy.

methodsLifetime cost-effectiveness analyses from both healthcare provider and societal perspectives were performed using Markov modelling by simulating at age 60. Empirical data on costs and health utility scores collected from our studies were combined with published data on health state transitions and survival data to estimate the lifetime cost, quality-adjusted life-years (QALYs) and cost-effectiveness of three competing dialysis modalities: peritoneal dialysis (PD), hospital-based haemodialysis (HD) and nocturnal home HD.

resultsFor cost-effectiveness analysis over a lifetime horizon from the perspective of healthcare provider, hospital-based HD group (lifetime cost USD$142,389; 6.58 QALYs) was dominated by the PD group (USD$76,915; 7.13 QALYs). Home-based HD had the highest effectiveness (8.37 QALYs) but with higher cost (USD$97,917) than the PD group. The incremental cost-effectiveness ratio (ICER) was USD$16,934 per QALY gained for home-based HD over PD. From the societal perspective, the results were similar and the ICER was USD$1195 per QALY gained for home-based HD over PD. Both ICERs fell within the acceptable thresholds. Changes in model parameters via sensitivity analyses had a minimal impact on ICER values.

conclusionsThis study assessed the cost-effectiveness of dialysis modalities and service delivery models for ESRD patients under "Peritoneal Dialysis First" policy. For both healthcare provider and societal perspectives, PD as first-line dialysis modality was cost-saving relative to hospital-based HD, supporting the existing PD First or favoured policy. When compared with PD, Nocturnal home Home-based HD was considered a cost-effective first-line dialysis modality for ESRD patients.

Indexed as

Cost-Benefit AnalysisHealth Care CostsHemodialysis, HomeHumansKidney Failure, ChronicMarkov ChainsMiddle AgedOutpatient Clinics, HospitalPeritoneal DialysisQuality-Adjusted Life YearsCost-effectivenessDialysisEconomic burdenEnd-stage renal diseaseNocturnal home haemodialysisPeritoneal dialysis first

Identifiers

PMID32019528
PMCPMC7001205

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.