ArticleBMC genetics2020
Parental warmth interacts with several genes to affect executive function components: a genome-wide environment interaction study.
Article in BMC genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Update on the relationship between theThe Journal of international medical research · 2023Pooled it
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample.Genes, brain, and behavior · 2023Article
- Parental interaction style, child engagement, and emerging executive function in fetal alcohol spectrum disorders (FASD).Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2022Article
- Article
- Using Genetic Marginal Effects to Study Gene-Environment Interactions with GWAS Data.Behavior genetics · 2021Article
- CPNE3 moderates the association between anxiety and working memory.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExecutive function (EF) is vital to human beings. It has been linked to many genes and family environmental factors in separate studies, but few studies have examined the potential interactions between gene(s) and environmental factor(s). The current study explored the whole genome to identify SNPs, genes, and pathways that interacted with parental warmth (PW) on EF.
resultsNine EF tasks were used to measure its three components (common EF, updating, shifting) based on the model proposed by Miyake et al. (2000). We found that rs111605473, LAMP5, SLC4A7, and LRRK1 interacted significantly with PW to affect the updating component of EF, and the GSE43955 pathway interacted significantly with PW to affect the common EF component.
conclusionsThe current study is the first to identify genes that interacted with PW to affect EF. Further studies are needed to reveal the underlying mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.