Evidence map›Paper›PMID 32019484›Full record

ArticleThe journal of headache and pain2020

Excess abdominal fat is associated with cutaneous allodynia in individuals with migraine: a prospective cohort study.

Ane Mínguez-Olaondo, Iván Martínez-Valbuena, Sonia Romero, Gema Frühbeck, María Rosario Luquin, Eduardo Martínez-Vila, Pablo Irimia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ane Mínguez-OlaondoDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain.
Iván Martínez-ValbuenaDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain.
Sonia RomeroEndocrinology and Nutrition Department, Clínica Universidad de Navarra, Pamplona, Spain.
Gema FrühbeckNavarra's Health Research Institute (IDISNA), Pamplona, Spain.
María Rosario LuquinDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain.
Eduardo Martínez-VilaDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain.
Pablo IrimiaDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain. pirimia@unav.es.ORCID http://orcid.org/0000-0002-7238-0036
Navarre Institute of Health Research · ESInstituto de Salud Carlos III · ESBiogipuzkoa Health Research Institute · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarkers in patients with and without CA.

backgroundExcess abdominal fat might facilitate progressive changes in nociceptive thresholds causing central sensitization, clinically reflected as CA, which could drive migraine progression.

methodsThis prospective cohort study included 80 patients with migraine (mean age 39 years, 81.2% female) and 39 non-migraine controls. We analysed each participant's height, body weight, and body mass index (BMI). The amount and distribution of BF was also assessed by air displacement plethysmography (ADP) and ViScan, respectively. We analysed serum levels of markers of inflammation, during interictal periods.

resultsWe studied 52 patients with episodic migraine (EM) and 28 with chronic migraine (CM). Of the 80 patients, 53 (53.8%) had CA. Migraineurs with CA had a higher proportion of abdominal fat values than patients without CA (p = 0.04). The independent risk factors for CA were the use of migraine prophylaxis (OR 3.26, 95% CI [1.14 to 9.32]; p = 0.03), proportion of abdominal fat (OR 1.13, 95% CI [1.01 to 1.27]; p = 0.04), and presence of sleep disorders (OR 1.13, 95% CI [00.01 to 1.27]; p = 0.04). The concordance correlation coefficient between the ADP and BMI measurements was 0.51 (0.3681 to 0.6247). CA was not correlated with the mean plasma levels of inflammatory biomarkers.

conclusionsThere is a relation between excess abdominal fat and CA. Abdominal obesity might contribute to the development of central sensitization in migraineurs, leading to migraine chronification.

Indexed as

Abdominal FatAdultBody Mass IndexBody WeightCentral Nervous System SensitizationDisease ProgressionFemaleHumansHyperalgesiaMaleMiddle AgedMigraine DisordersObesityProspective StudiesRisk FactorsAbdominal fatBiomarkerBMIBody compositionBody fatCutaneous allodyniaInflammationMigraine chronificationRisk factors

Identifiers

PMID32019484
PMCPMC7001192
OpenAlexW3009146232

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.