Evidence map›Paper›PMID 32019393›Full record

ArticleEpigenetics2020

CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain.

Noemi Monti, Rosaria A Cavallaro, Andrea Stoccoro, Vincenzina Nicolia, Sigfrido Scarpa, Gabor G Kovacs, Maria Teresa Fiorenza, Marco Lucarelli, Eleonora Aronica, Isidre Ferrer and 3 more

Open access · greenAbstract read
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
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  6. Epigenetics in Neurodegenerative Diseases.Sub-cellular biochemistry · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Epigenetic modifications of DNA and RNA in Alzheimer's disease.Frontiers in molecular neuroscience · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Perinatal S-Adenosylmethionine Supplementation RepressesInternational journal of molecular sciences · 2023
    Article
  17. International journal of molecular sciences · 2023
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Noemi MontiDepartment of Experimental Medicine, Sapienza University of Rome , Rome, Italy.
Rosaria A CavallaroDepartment of Surgery "P. Valdoni", Sapienza University of Rome , Rome, Italy.
Andrea StoccoroDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa , Pisa, Italy.
Vincenzina NicoliaDepartment of Surgery "P. Valdoni", Sapienza University of Rome , Rome, Italy.
Sigfrido ScarpaDepartment of Surgery "P. Valdoni", Sapienza University of Rome , Rome, Italy.
Gabor G KovacsInstitute of Neurology, Medical University of Vienna , Vienna, Austria.
Maria Teresa FiorenzaDepartment of Psychology, Division of Neuroscience, Sapienza University of Rome , Rome, Italy.ORCID 0000-0002-5079-4019
Marco LucarelliDepartment of Experimental Medicine, Sapienza University of Rome , Rome, Italy.ORCID 0000-0002-5538-2494
Eleonora AronicaDepartment of (Neuro) Pathology, Neuroscience, Amsterdam UMC, University of Amsterdam , Amsterdam, The Netherlands.
Isidre FerrerNeuropathology, Service of Pathology, Bellvitge University Hospital , Barcelona, Spain.ORCID 0000-0001-9888-8754
Fabio CoppedèDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa , Pisa, Italy.
Aron M TroenNutrition and Brain Health Laboratory, the Institute of Biochemistry Food and Nutrition Science, the Robert H. Smith Faculty of Agriculture Food and the Environment, The Hebrew University of Jerusalem , Jerusalem, Israel.ORCID 0000-0001-9738-2524
Andrea FusoDepartment of Experimental Medicine, Sapienza University of Rome , Rome, Italy.ORCID 0000-0001-9467-5671
Sapienza University of Rome · ITUniversity of Pisa · ITAmsterdam Neuroscience · NLBellvitge University Hospital · ESFondazione Santa Lucia · ITHebrew University of Jerusalem · ILIstituto Pasteur · ITMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Presenilin1 (

Indexed as

DNA MethylationAgedAged, 80 and overAlzheimer DiseaseAnimalsBrainCpG IslandsFemaleHumansMaleMicePresenilin-1Presenilin-1PSEN1 protein, humanAlzheimer’s DiseaseDNA methylationMIPs (non-CpG Methylation-Insensitive Primers)neurodegenerationneurodevelopmentnon-CpG methylationPresenilin1

Identifiers

PMID32019393
PMCPMC7518704
OpenAlexW3004792393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.