Evidence map›Paper›PMID 32019333›Full record

ArticleAIDS care2020

Newly diagnosed HIV positive children: a unique index case to improve HIV diagnosis and linkage to care of parents.

Jillian Neary, Irene N Njuguna, Lisa M Cranmer, Vincent O Otieno, Cyrus Mugo, Hellen M Okinyi, Sarah Benki-Nugent, Barbra A Richardson, Joshua Stern, Elizabeth Maleche-Obimbo and 3 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in AIDS care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02063880 (Urgent Versus Post-Stabilization ART in HIV-1 Infected Children With Severe Co-Infections), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02063880 nacompletednot on this map

Urgent Versus Post-Stabilization ART in HIV-1 Infected Children With Severe Co-Infections

TypeinterventionalSponsorUniversity of WashingtonRan2013 to 2015Enrolled183ConditionsHuman Immunodeficiency Virus, Immune Reconstitution Inflammatory SyndromeArmsUrgent ART, Early ART
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Jillian NearyDepartments of Global Health, University of Washington, Seattle, WA, USA.
Irene N NjugunaDepartments of Epidemiology, University of Washington, Seattle, WA, USA.
Lisa M CranmerDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Vincent O OtienoKenya Medical Research Institute, Kisumu, Kenya.
Cyrus MugoDepartments of Global Health, University of Washington, Seattle, WA, USA.
Hellen M OkinyiDepartment of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Sarah Benki-NugentDepartments of Global Health, University of Washington, Seattle, WA, USA.
Barbra A RichardsonDepartments of Global Health, University of Washington, Seattle, WA, USA.
Joshua SternDepartments of Biostatistics, University of Washington, Seattle, WA, USA.
Elizabeth Maleche-ObimboDepartment of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Dalton C WamalwaDepartment of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Grace C John-StewartDepartments of Global Health, University of Washington, Seattle, WA, USA.
Anjuli D WagnerDepartments of Global Health, University of Washington, Seattle, WA, USA.
University of Washington · USUniversity of Nairobi · KEEmory University · USKenya Medical Research Institute · KEKenyatta National Hospital · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Urgent Versus Post-Stabilization ART in HIV+ Children with Severe Co-infectionsR01HD023412 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, DALTON CHEKOKO WAMALWA · 1987 to 2026
$12.2M
Promoting Diversity, Equity, and Inclusivity in Research Training to Optimize HIV Prevention and TreatmentD43TW009580 · FIC · UNIVERSITY OF WASHINGTON · PI CAREY FARQUHAR, John Kinuthia · 2013 to 2026
$4.8M
Women and HIV: Translation of Research into Practice-WLHIV Post-Graduate Research FellowshipD43TW009783 · FIC · UNIVERSITY OF WASHINGTON · PI Elizabeth Anne BUKUSI, CAREY FARQUHAR · 2015 to 2026
$4.1M
Health-Professional Education Partnership Initiative (HEPI) - KenyaR25TW011212 · FIC · UNIVERSITY OF NAIROBI · PI NDUATI, RUTH WANJIRU, WAMALWA, DALTON CHEKOKO · 2018 to 2022
$3.2M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
The role of antibodies in infant TB preventionK23AI143479 · NIAID · EMORY UNIVERSITY · PI CRANMER, LISA M · 2019 to 2023
$950k
Impact of HIV, immune activation, and ART on child neurodevelopment in KenyaK01NS080637 · NINDS · UNIVERSITY OF WASHINGTON · PI BENKI-NUGENT, SARAH F. · 2012 to 2016
$848k
Systems analysis and improvement approach to improve pediatric HIV testing and linkage to careF32HD088204 · NICHD · UNIVERSITY OF WASHINGTON · PI WAGNER, ANJULI DAWN · 2016 to 2019
$168k
FIC NIH HHS D43 TW009580FIC NIH HHS D43 TW009783FIC NIH HHS R25 TW011212NIAID NIH HHS K23 AI143479NIAID NIH HHS P30 AI027757NICHD NIH HHS F32 HD088204NICHD NIH HHS K12 HD000850NICHD NIH HHS K24 HD054314NICHD NIH HHS R01 HD023412NINDS NIH HHS K01 NS080637
6 · The paper itself

Abstract

Newly diagnosed HIV positive children may be unique index cases to identify undiagnosed parents. Data was used from the Pediatric Urgent Start of HAART (NCT02063880) trial, which enrolled hospitalized, ART-naïve, HIV positive children ages 0-12 years in Kenya. Exact McNemar's tests were used to compare proportions of mothers and fathers tested for HIV, linked to care, and on ART at baseline and 6 months. This analysis included 87 newly diagnosed children with HIV who completed 6 months of follow-up. Among 83 children with living mothers, there were improvements in maternal linkage to care and treatment comparing baseline to 6 months (36% vs. 78%;

Indexed as

Antiretroviral Therapy, Highly ActiveHIV InfectionsChildChild, PreschoolDelivery of Health CareEarly DiagnosisFemaleHumansInfantInfant, NewbornKenyaMaleMothersParentscase identificationfamily testingHIVHIV care cascadeHIV testingindex case testing

Identifiers

PMID32019333
PMCPMC7398832
OpenAlexW3004886496

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.