ArticleMarine drugs2020
Mining Natural Product Biosynthesis in Eukaryotic Algae.
Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Genomic-Driven Identification of Conserved Biosynthetic Gene Clusters inMetabolites · 2026Article
- Article
- Natural Antimicrobial Agents from Algae: Current Advances and Future Directions.International journal of molecular sciences · 2024Review
- Harmful Microalgae Exhibit Broad Environmental Adaptability in High-Salinity Area Across the Dafengjiang River Estuary.Ecology and evolution · 2024Article
- Genomic analysis of Coccomyxa viridis, a common low-abundance alga associated with lichen symbioses.Scientific reports · 2023Article
- Biosynthetic Potential ofJournal of fungi (Basel, Switzerland) · 2023Article
- Plant biosynthetic gene clusters in the context of metabolic evolution.Natural product reports · 2022Review
- Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction.Acta pharmaceutica Sinica. B · 2022Review
- Antifouling Activity of Halogenated Compounds Derived from the Red AlgaMarine drugs · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Eukaryotic algae are an extremely diverse category of photosynthetic organisms and some species produce highly potent bioactive compounds poisonous to humans or other animals, most notably observed during harmful algal blooms. These natural products include some of the most poisonous small molecules known and unique cyclic polyethers. However, the diversity and complexity of algal genomes means that sequencing-based research has lagged behind research into more readily sequenced microbes, such as bacteria and fungi. Applying informatics techniques to the algal genomes that are now available reveals new natural product biosynthetic pathways, with different groups of algae containing different types of pathways. There is some evidence for gene clusters and the biosynthetic logic of polyketides enables some prediction of these final products. For other pathways, it is much more challenging to predict the products and there may be many gene clusters that are not identified with the automated tools. These results suggest that there is a great diversity of biosynthetic capacity for natural products encoded in the genomes of algae and suggest areas for future research focus.
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Registered trials
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