ArticleThe Science of the total environment2020
Pilot study of global endocrine disrupting activity in Iowa public drinking water utilities using cell-based assays.
Article in The Science of the total environment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Mixed contaminant exposure in tapwater and the potential implications for human-health in disadvantaged communities in California.Water research · 2024Article
- Novel biosensor for high-throughput detection of progesterone receptor-interacting endocrine disruptors.Scientific reports · 2024Article
- Integrating different tools and technologies to advance drinking water quality exposure assessments.Journal of exposure science & environmental epidemiology · 2024Review
- The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease.Open research Europe · 2024Article
- Cytotoxicity of water supply in a Palestinian refugee camp and a Syrian informal tented settlement in Lebanon.PloS one · 2024Article
- Juxtaposition of intensive agriculture, vulnerable aquifers, and mixed chemical/microbial exposures in private-well tapwater in northeast Iowa.The Science of the total environment · 2023Article
- A Current Review of Water Pollutants in American Continent: Trends and Perspectives in Detection, Health Risks, and Treatment Technologies.International journal of environmental research and public health · 2023Review
- Article
- Drinking Water Disinfection Byproducts, Ingested Nitrate, and Risk of Endometrial Cancer in Postmenopausal Women.Environmental health perspectives · 2022Article
- Endocrine disruptors of sex hormone activities.Molecular and cellular endocrinology · 2022Review
- Mapping multiple endocrine disrupting activities in Virginia rivers using effect-based assays.The Science of the total environment · 2021Article
- Chemical and in vitro bioanalytical assessment of drinking water quality in Manhiça, Mozambique.Journal of exposure science & environmental epidemiology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
Some anthropogenic substances in drinking water are known or suspected endocrine disrupting compounds (EDCs), but EDCs are not routinely measured. We conducted a pilot study of 10 public drinking water utilities in Iowa, where common contaminants (e.g., pesticides) are suspected EDCs. Raw (untreated) and finished (treated) drinking water samples were collected in spring and fall and concentrated using solid phase extraction. We assessed multiple endocrine disrupting activities using novel mammalian cell-based assays that express nuclear steroid receptors (aryl hydrocarbon [AhR], androgenic [AR], thyroid [TR], estrogenic [ER] and glucocorticoid [GR]). We quantified each receptor's activation relative to negative controls and compared activity by season and utility/sample characteristics. Among 62 samples, 69% had AhR, 52% AR, 3% TR, 2% ER, and 0% GR activity. AhR and AR activities were detected more frequently in spring (p =0 .002 and < 0.001, respectively). AR activity was more common in samples of raw water (p =0 .02) and from surface water utilities (p =0 .05), especially in fall (p =0 .03). Multivariable analyses suggested spring season, surface water, and nitrate and disinfection byproduct concentrations as determinants of bioactivity. Our results demonstrate that AR and AhR activities are commonly found in Iowa drinking water, and that their detection varies by season and utility/sample characteristics. Screening EDCs with cell-based bioassays holds promise for characterizing population exposure to diverse EDCs mixtures.
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Registered trials
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