ArticlePloS one2020
Characterizing the role of Zn cluster family transcription factor ZcfA in governing development in two Aspergillus species.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Contribution of MylA in Conidiogenesis, Conidia Germination, and beta-Glucan Biosynthesis inJournal of microbiology and biotechnology · 2026Article
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- The MYB-like protein MylA contributes to conidiogenesis and conidial germination in Aspergillus nidulans.Communications biology · 2024Article
- Integration of Physiological, Transcriptomic and Metabolomic Reveals Molecular Mechanism ofJournal of fungi (Basel, Switzerland) · 2023Article
- Regulators of the Asexual Life Cycle ofCells · 2023Review
- srdA mutations suppress the rseA/cpsA deletion mutant conidiation defect in Aspergillus nidulans.Scientific reports · 2023Article
- Homeobox transcription factor HbxA influences expression of over one thousand genes in the model fungus Aspergillus nidulans.PloS one · 2023Article
- The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi.Microbiology and molecular biology reviews : MMBR · 2022Review
- Composition and Codon Usage Pattern Results in Divergence of theJournal of fungi (Basel, Switzerland) · 2022Article
- The function of a conidia specific transcription factor CsgA in Aspergillus nidulans.Scientific reports · 2022Article
- Regulation of Conidiogenesis inCells · 2022Review
- Unveiling the Functions of the VosA-VelB Target GeneMycobiology · 2021Article
- Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans.Scientific reports · 2020Article
- TheInternational journal of molecular sciences · 2020Article
- Homeobox proteins are essential for fungal differentiation and secondary metabolism in Aspergillus nidulans.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamentous fungi reproduce asexually or sexually, and the processes of asexual and sexual development are tightly regulated by a variety of transcription factors. In this study, we characterized a Zn2Cys6 transcription factor in two Aspergillus species, A. nidulans (AN5859) and A. flavus (AFLA_046870). AN5859 encodes a Zn2Cys6 transcription factor, called ZcfA. In A. nidulans, ΔzcfA mutants exhibit decreased fungal growth, a reduction in cleistothecia production, and increased asexual reproduction. Overexpression of zcfA results in increased conidial production, suggesting that ZcfA is required for proper asexual and sexual development in A. nidulans. In conidia, deletion of zcfA causes decreased trehalose levels and decreased spore viability but increased thermal sensitivity. In A. flavus, the deletion of the zcfA homolog AFLA_046870 causes increased conidial production but decreased sclerotia production; these effects are similar to those of zcfA deletion in A. nidulans development. Overall, these results demonstrate that ZcfA is essential for maintaining a balance between asexual and sexual development and that some roles of ZcfA are conserved in Aspergillus spp.
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