Evidence map›Paper›PMID 32017574›Full record

ArticleOrganic letters2020

MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product.

Fan Zhang, Thomas P Wyche, Yanlong Zhu, Doug R Braun, Jia-Xuan Yan, Shaurya Chanana, Ying Ge, Ilia A Guzei, Marc G Chevrette, Cameron R Currie and 3 more

Abstract read
In one paragraph

Article in Organic letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fan ZhangPharmaceutical Sciences Division , University of Wisconsin-Madison , Madison , Wisconsin 53705 , United States.
Thomas P WycheMerck & Co., Inc. , 320 Bent Street , Cambridge , Massachusetts 02141 , United States.
Yanlong ZhuDepartment of Cell and Regenerative Biology , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Doug R BraunPharmaceutical Sciences Division , University of Wisconsin-Madison , Madison , Wisconsin 53705 , United States.
Jia-Xuan YanPharmaceutical Sciences Division , University of Wisconsin-Madison , Madison , Wisconsin 53705 , United States.
Shaurya ChananaPharmaceutical Sciences Division , University of Wisconsin-Madison , Madison , Wisconsin 53705 , United States.
Ying GeDepartment of Cell and Regenerative Biology , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.ORCID 0000-0001-5211-6812
Ilia A GuzeiDepartment of Chemistry , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.ORCID 0000-0003-1976-7386
Marc G ChevretteDepartment of Genetics , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.ORCID 0000-0002-7209-0717
Cameron R CurrieDepartment of Bacteriology , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Michael G ThomasDepartment of Bacteriology , University of Wisconsin-Madison , Madison , Wisconsin 53706 , United States.
Scott R RajskiPharmaceutical Sciences Division , University of Wisconsin-Madison , Madison , Wisconsin 53705 , United States.
Tim S BugniPharmaceutical Sciences Division , University of Wisconsin-Madison , Madison , Wisconsin 53705 , United States.ORCID 0000-0002-4502-3084

Funding

Novel antimicrobials targeting MDR pathogens from animal microbial symbiontsU19AI142720 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R · 2019 to 2023
$30.1M
Metabolomics driven discovery of drug leads from symbiotic bacteriaU19AI109673 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, CURRIE, CAMERON ROBERT · 2014 to 2018
$16.2M
TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2012 to 2019
$9.4M
Omics approaches for natural products discoveryR01GM104192 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUGNI, TIMOTHY S · 2013 to 2019
$2.0M
NIAID NIH HHS U19 AI109673NIAID NIH HHS U19 AI142720NIGMS NIH HHS P41 GM103399NIGMS NIH HHS R01 GM104192
6 · The paper itself

Abstract

Forazoline A is a structurally complex PKS-NRPS hybrid produced by marine-derived

Indexed as

ActinomycetalesBiological ProductsIsotopesMass SpectrometryMolecular ConformationPolyketidesBiological Productsforazoline AIsotopesPolyketides

Identifiers

PMID32017574
PMCPMC7494057

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.