ArticleArthritis & rheumatology (Hoboken, N.J.)2020
Aberrant Salience? Brain Hyperactivation in Response to Pain Onset and Offset in Fibromyalgia.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- Modulation of Posterior Insula Selectively Enhances Nociceptive Sensory Gating in Humans.medRxiv : the preprint server for health sciences · 2026Article
- Central Sensitization and Nociplastic Pain: Shared Mechanisms in Fibromyalgia, Osteoarthritis, and Inflammatory Arthritis.Journal of pain research · 2026Review
- Machine learning for the diagnosis of fibromyalgia based on magnetic resonance imaging.PloS one · 2026Article
- Descending Pain Modulation in Fibromyalgia: A Short Review of Mechanisms and Biomarkers.Diagnostics (Basel, Switzerland) · 2025Review
- Can Gratitude Ease the Burden of Fibromyalgia? A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- Multidimensional Effects of Manual Therapy Combined with Pain Neuroscience-Based Sensorimotor Retraining in a Patient with Chronic Neck Pain: A Case Study Using fNIRS.Healthcare (Basel, Switzerland) · 2025Article
- How does chronic psychosocial distress induce pain? Focus on neuroinflammation and neuroplasticity changes.Brain, behavior, & immunity - health · 2025Article
- Gender Differences in Amplitude of Low-Frequency Fluctuation Alterations in Healthy Volunteers by Acupuncture on Left "LI 15": A Resting-State fMRI Study.Behavioural neurology · 2024Article
- Does practice make perfect? Functional connectivity of the salience network and somatosensory network predicts response to mind-body treatments for fibromyalgia.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head.Neural regeneration research · 2022Article
- The puzzle of fibromyalgia between central sensitization syndrome and small fiber neuropathy: a narrative review on neurophysiological and morphological evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Sound-Induced Flash Illusions Support Cortex Hyperexcitability in Fibromyalgia.Pain research & management · 2022Article
- Research in Mindfulness Interventions for Patients With Fibromyalgia: A Critical Review.Frontiers in integrative neuroscience · 2022Review
- 3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia.European journal of pain (London, England) · 2021Article
- Fibromyalgia Detection Based on EEG Connectivity Patterns.Journal of clinical medicine · 2021Article
- How fMRI Analysis Using Structural Equation Modeling Techniques Can Improve Our Understanding of Pain Processing in Fibromyalgia.Journal of pain research · 2021Article
- Involvement of Parvalbumin-Positive Neurons in the Development of Hyperalgesia in a Mouse Model of Fibromyalgia.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Assessing our approach to diagnosing Fibromyalgia.Expert review of molecular diagnostics · 2020Review
- Exploring the hypothetical role of cerebellar pain prediction errors in fibromyalgia-associated chronic pain.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveWhile much brain research on fibromyalgia (FM) focuses on the study of hyperresponsiveness to painful stimuli, some studies suggest that the increased pain-related brain activity often reported in FM studies may be partially explained by stronger responses to salient aspects of the stimulation rather than, or in addition to, the stimulation's painfulness. Therefore, this study was undertaken to test our hypothesis that FM patients would demonstrate elevated brain responses to both pain onset and offset-2 salient sensory events of opposing valences.
methodsThirty-eight FM patients (mean ± SD age 46.1 ± 13.4 years; 33 women) and 15 healthy controls (mean ± SD age 45.5 ± 12.4; 10 women) received a moderately painful pressure stimulus to the leg during blood oxygen level-dependent (BOLD) functional magnetic resonance imaging. Stimulus onset and offset transients were analyzed using a general linear model as stick functions.
resultsDuring pain onset, higher BOLD signal response was observed in FM patients compared to healthy controls in dorsolateral and ventrolateral prefrontal cortices (DLPFC and VLPFC, respectively), orbitofrontal cortex (OFC), frontal pole, and precentral gyrus (PrCG). During pain offset, higher and more widespread BOLD signal response was demonstrated in FM patients compared to controls in frontal regions significantly hyperactivated in response to onset. In FM patients, some of these responses were positively correlated with pain unpleasantness ratings (VLPFC, onset; r = 0.35, P = 0.03), pain catastrophizing scores (DLPFC, offset; r = 0.33, P = 0.04), or negatively correlated with stimulus intensity (OFC, offset; r = -0.35, P = 0.03) (PrCG, offset; r = -0.39, P = 0.02).
conclusionOur results suggest that the increased sensitivity exhibited by FM patients in response to the onset and offset of painful stimuli may reflect a more generalized hypersensitivity to salient sensory events, and that brain hyperactivation may be a mechanism potentially involved in the generalized hypervigilance to salient stimuli in FM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.