Evidence map›Paper›PMID 32017376›Full record

ArticleMolecular oncology2020

The potential of combined mutation sequencing of plasma circulating cell-free DNA and matched white blood cells for treatment response prediction.

Paul van der Leest, Ed Schuuring

Abstract readComment
In one paragraph

Article in Molecular oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Paul van der LeestLaboratory of Molecular Pathology, Department of Pathology (EA10), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-8527-4956
Ed SchuuringLaboratory of Molecular Pathology, Department of Pathology (EA10), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-3655-143X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly sensitive mutation detection methods enable the application of circulating cell-free DNA for molecular tumor profiling. Recent studies revealed that sequencing artifacts, germline variants, and clonal hematopoiesis confound the interpretation of sequencing results and complicate subsequent treatment decision making and disease monitoring. Parallel sequencing of matched white blood cells promises to overcome these issues and enables appropriate variant calling. Comment on: https://doi.org/10.1002/1878-0261.12617.

Indexed as

Cell-Free Nucleic AcidsHigh-Throughput Nucleotide SequencingHumansLeukocytesMutationPlasmaCell-Free Nucleic Acids

Identifiers

PMID32017376
PMCPMC7053232

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.