ArticleJournal of clinical laboratory analysis2020
High level of D-dimer predicts ischemic stroke in patients with infective endocarditis.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Association between prothrombin time activity and short-term outcomes in patients with infective endocarditis.BMC infectious diseases · 2026Article
- Review
- Serum Biomarkers in Acute Ischemic Stroke: Clinical Applications and Emerging Insights.Journal of clinical medicine · 2025Review
- Embolic risk management in infective endocarditis: predicting the 'embolic roulette'.Open heart · 2025Review
- Infective endocarditis in a Finnish tertiary care hospital: from etiology to embolic events.Annals of medicine · 2024Article
- Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis-Related Stroke, 2005-2015.Neurology · 2023Article
- A Bayesian network-based approach for identifying risk factors and predicting ischemic stroke in infective endocarditis patients.Frontiers in cardiovascular medicine · 2023Article
- Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study.Infection and drug resistance · 2022Article
- Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis.Journal of clinical medicine · 2021Article
- Infective endocarditis complicated by embolic events: Pathogenesis and predictors.Clinical cardiology · 2021Review
- Central nervous system as a target of novel coronavirus infections: Potential routes of entry and pathogenic mechanisms.Journal of biosciences · 2021Review
- High level of D-dimer predicts ischemic stroke in patients with infective endocarditis.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemic stroke is one of the most prominent and serious neurological complications of infective endocarditis (IE). Our study was designed to evaluate the predictive value of higher level of plasma D-dimer on admission for the development of ischemic stroke in patients with IE.
methodsIn this prospective study, a total of 173 consecutive patients with IE were recruited from January 2016 to December 2018. Plasma D-dimer and other clinical indexes of IE patients were measured after admission. The number of patients who developed ischemic stroke during 6-month follow-up was recorded, as well as the occurrence time of ischemic stroke.
resultsIschemic stroke was observed in 38 (22%) patients during 6-month follow-up since definite diagnosis of IE. Patients with ischemic stroke had significantly higher levels of plasma D-dimer than those of patients without stroke (4982 vs 2205 μg/L, P < .001). In addition, Staphylococcus aureus infection (HR: 1.96, 95% CI: 1.51-2.42), mitral valve vegetation (HR: 1.52, 95% CI: 1.32-1.75), and higher levels of on-admission plasma D-dimer (HR: 1.35, 95% CI: 1.27-1.43) were significantly associated with ischemic stroke. Moreover, D-dimer levels ≥3393 μg/L served as a strong predictor for ischemic stroke in patients with IE, and the sensitivity and specificity were 78% and 83%, respectively.
conclusionOur study suggested that higher level of D-dimer on admission was an independent predictor for ischemic stroke in patients with IE. These patients may require special attention, in particular within the first trimester after IE diagnosis.
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