ArticleDrugs & aging2020
Prevalence and Factors Associated with Analgesic Prescribing in Poly-Medicated Elderly Patients.
Article in Drugs & aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Are Mind-Body Exercise Beneficial for Treating Pain, Function, and Quality of Life in Middle-Aged and Old People With Chronic Pain? A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2022Pooled it
- Optimal modes of mind-body exercise for treating chronic non-specific low back pain: Systematic review and network meta-analysis.Frontiers in neuroscience · 2022Pooled it
- Emotional Awareness and Expression Therapy vs Cognitive Behavioral Therapy for Chronic Pain in Older Veterans: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Multi-Institutional Drug Use Patterns in Hospitalized Older Patients: Retrospective Cross-Sectional Study.JMIR medical informatics · 2026Article
- Factors potentiating risk of higher lactate level associated with metformin therapy: a cross-sectional study in an ambulatory care setting.Therapeutic advances in endocrinology and metabolism · 2026Article
- Clinical Validation of Quality Indicators for the Pharmacological Management of Chronic Non-Cancer Pain in Older Adult Inpatients.Journal of pain research · 2026Article
- Factors associated with creatine kinase variability among statin users in routine outpatient care: a retrospective cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Review
- Pain assessment and management of adult patients in the Swedish EMS: a nationwide registry study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Observational
- Amlodipine and frusemide: pharmacological factors contributing to increased fall risk in concurrently treated patients - a retrospective cross-sectional study.Frontiers in pharmacology · 2025Article
- Pharmacological Pain Treatment in Older Persons.Drugs & aging · 2024Review
- Prescribing Hydroxyurea in Sickle Cell Disease Patients: The Pattern and Association with Co-Prescribed Medications Used to Manage the Disease Complications.Journal of clinical medicine · 2024Article
- Pattern of Prescribing Proton Pump Inhibitors: Evaluating Appropriateness and Factors Contributing to Their Adverse Effect Reaction Risk.Journal of clinical medicine · 2024Article
- The prevalence of polypharmacy and hyper-polypharmacy among middle-aged vsFrontiers in pharmacology · 2024Article
- An alternative treatment option in older adults with knee osteoarthritis : Genicular nerve pulsed radiofrequency.Wiener klinische Wochenschrift · 2023Article
- Medicine and supplement use in infants, children, and adolescents depends on sex, age, and socioeconomic status: results of a German longitudinal population-based cohort study (LIFE Child).European journal of pediatrics · 2022Article
- Population Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients.European journal of drug metabolism and pharmacokinetics · 2022Article
- Sex-specific analysis of traumatic brain injury events: applying computational and data visualization techniques to inform prevention and management.BMC medical research methodology · 2022Article
- Population pharmacokinetic model of subcutaneous fentanyl in older acute care patients.European journal of clinical pharmacology · 2021Article
- Opioid prescribing and risk of drug-opioid interactions in older discharged patients with polypharmacy in Australia.International journal of clinical pharmacy · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPain is common in older patients and management guidelines rarely consider the effect of multiple comorbidities and concurrent medications on analgesic selection.
objectivesThe objectives of this study were to identify the prevalence and pattern of analgesic prescribing and associated factors in older patients with polypharmacy.
methodsOlder patients (aged ≥ 75 years) admitted to the Royal Adelaide Hospital between September 2015 and August 2016 and with polypharmacy were included and their comorbidities and medications prescribed at discharge were recorded. Drug Burden Index and Charlson Comorbidity Index were calculated. The number of medications that increased the risk of orthostatic hypotension were recorded. Logistic regression was used to compute the association between analgesic use and participant characteristics, and results were presented as odds ratios and 95% confidence intervals, adjusted for age, sex, Charlson Comorbidity Index, Drug Burden Index and orthostatic hypotension.
resultsOver 15,000 admissions were identified, of which 1192 patients were included, 824 (69%) of whom were prescribed an analgesic medication. Paracetamol (used by 89% of analgesic users), opioids (34%) and adjuvants (17%) were used more frequently than non-steroidal anti-inflammatory drugs (8%). Analgesic users had a higher Drug Burden Index, were prescribed more medications and were less likely to be male compared with non-users. Charlson Comorbidity Index across the cohort was high (7.3 ± 1.9) but there was no difference between analgesic users and non-users, but analgesic users were more likely to have a documented diagnosis of osteoarthritis, osteoporosis and falls. Opioid use was associated with the Drug Burden Index, while adjuvant use was associated with orthostatic hypotension. Opioid use was associated with having a diagnosis of osteoporosis and falls.
conclusionsIn our cohort of poly-medicated elderly patients, prescription of analgesic medications was common, and these patients are likely to have an increased rate of adverse drug reactions and falls compared with those who were not prescribed analgesic medications.
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