Evidence map›Paper›PMID 32016807›Full record

ArticleMycotoxin research2020

Ochratoxin A in human blood plasma samples from apparently healthy volunteers in Nanjing, China.

Kai Fan, Xi Cheng, Wenbo Guo, Xing Liu, Zhiqi Zhang, Qi Yao, Dongxie Nie, Bing Yao, Zheng Han

Abstract read
PubMed Publisher
In one paragraph

Article in Mycotoxin research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kai Fan *Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University, School of Medicine, Nanjing, 210002, Jiangsu, China.
Xi Cheng *Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University, School of Medicine, Nanjing, 210002, Jiangsu, China.
Wenbo GuoInstitute for Agro-food Standards and Testing Technology, Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China.
Xing LiuInstitute for Agro-food Standards and Testing Technology, Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China.
Zhiqi ZhangInstitute for Agro-food Standards and Testing Technology, Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China.
Qi YaoDepartment of Pathology and Pathophysiology, School of Medicine and Life Sciences, Nanjing University of Traditional Chinese Medicine, Nanjing, 210023, Jiangsu, China.
Dongxie NieInstitute for Agro-food Standards and Testing Technology, Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China.
Bing YaoReproductive Medical Center, Nanjing Jinling Hospital, Nanjing University, School of Medicine, Nanjing, 210002, Jiangsu, China. yaobing@nju.edu.cn.
Zheng HanInstitute for Agro-food Standards and Testing Technology, Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China. hanzheng@saas.sh.cn.
Shanghai Academy of Agricultural Sciences · CNNanjing General Hospital of Nanjing Military Command · CNNanjing University · CN

Funding

National Natural Science Foundation of China 31671950National Natural Science Foundation of China 31972178Science and Technology Commission of Shanghai Municipality 18395810100Shanghai Municipal Agricultural Commission 20170130
6 · The paper itself

Abstract

This study was conducted to investigate the exposure to ochratoxin A (OTA) of populations living in Nanjing, China. Plasma samples were collected from 147 healthy adults (age 18-63 years) and analyzed for OTA by a reliable and sensitive ultra-high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method (limit of detection 0.04 ng/mL). After enzymatic hydrolysis by β-glucuronidase/arylsulfatase, OTA was detected in 80.9% plasma samples with mean concentration of 0.26 ± 0.59 ng/mL (range 0.04-6.59 ng/mL). The estimated daily intakes of OTA based on plasma concentrations (mean 0.51 ng/kg bw/day, max 12.99 ng/kg bw/day) were lower than the tolerable daily intake published by European Food Safety Authority (EFSA) or Joint FAO/WHO Expert Committee on Food Additives (JFECFA) indicative of rare risks related to the OTA exposure in the investigated area. This study provides a valuable insight on human exposure to OTA in China. Further studies in children and elder people and in adult cohorts from other regions are recommended.

Indexed as

AdolescentAdultChinaChromatography, LiquidDietary ExposureFemaleHealthy VolunteersHumansMaleMiddle AgedOchratoxinsPlasmaTandem Mass SpectrometryYoung Adultochratoxin AOchratoxinsBiomarkerExposure assessmentOchratoxin APlasma

Identifiers

PMID32016807
OpenAlexW3004460054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.