ArticleJapanese journal of ophthalmology2020
Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis.
Article in Japanese journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Case report: When Behçet's disease meets multizonal outer retinopathy and retinal pigment epitheliopathy: longitudinal multimodal imaging of an overlap phenotype.Frontiers in immunology · 2026Article
- Analysis of prognostic factors in acute retinal necrosis using ultrawide-field fundus imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- "Infectious uveitis: a comprehensive systematic review of emerging trends and molecular pathogenesis using network analysis".Journal of ophthalmic inflammation and infection · 2024Review
- Characterization and prevalence of ocular comorbidities and risk of legal blindness across the United States.Eye (London, England) · 2024Article
- Proteome Analysis of Bevacizumab Intervention in Experimental Central Retinal Vein Occlusion.Journal of personalized medicine · 2023Article
- Article
- Syphilitic uveitis in HIV-positive patients: report of a case series, treatment outcomes, and comprehensive review of the literature.International journal of ophthalmology · 2023Article
- Vasculitis associated with the use of an intrauterine device: A case report.Experimental and therapeutic medicine · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
purposeRetinal vasculitis and occlusive changes are important signs of posterior uveitis and are possible diagnostic markers for uveitis. However, the frequency of arteritis and phlebitis in various uveitis entities, including infectious uveitis (IU) and non-infectious uveitis (NIU), have not been systematically investigated. STUDY
designRetrospective.
methodsWe investigated the frequency of retinal vascular inflammatory and occlusive changes in patients with IU and NIU. The study included 283 patients with intermediate, posterior, or pan-uveitis who were diagnosed with IU (presumed tuberculous uveitis, acute retinal necrosis, cytomegalovirus retinitis, human T-cell lymphotropic virus type 1-associated uveitis, toxoplasmic retinitis, syphilitic uveitis, rubella virus-associated uveitis, fungal endophthalmitis, and bacterial endophthalmitis) or NIU (sarcoidosis, Behçet's disease, Vogt-Koyanagi-Harada disease, human leukocyte antigen-B27-associated uveitis, systemic lupus erythematosus retinopathy, psoriatic uveitis, rheumatoid arthritis/collagen disease-associated uveitis, multiple sclerosis-associated uveitis, and sympathetic ophthalmia). All patients underwent fluorescein angiography (FA) and color photography examinations of the fundus. Presence of inflammatory and occlusive changes was determined by FA images.
resultsSignificantly higher positive ratios of phlebitis, vein sheathing, vein occlusion, arteritis, artery sheathing, artery occlusion, and avascular areas were observed in the IU group than in the NIU group (p < 0.05). Notably, the discrepancy between IU and NIU was prominent with regard to retinal arterial changes (arteritis [57.9% vs 11.2%], inflammatory artery sheathing [33.7% vs 0%], and artery occlusion [22.1% vs 3.7%], respectively; p < 0.0001).
conclusionFindings of vasculitis and occlusion, especially in retinal arteries, in FA strongly suggest an infectious origin of active uveitis.
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