Evidence map›Paper›PMID 32016634›Full record

ArticleMolecular biology reports2020

Combretastatin A-4 disodium phosphate and low dose gamma irradiation suppress hepatocellular carcinoma by downregulating ROCK1 and VEGF gene expression.

Zakaria Mohamed Alghzzawy, Tarek Khaled Elmaghraby, Sanaa Abd El-Hamid Hagag, Mohammed Hussein Awwad

Abstract read
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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zakaria Mohamed AlghzzawyRadiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo, Egypt.
Tarek Khaled ElmaghrabyRadiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo, Egypt. tarekmag40@hotmail.com.ORCID http://orcid.org/0000-0002-5663-4323
Sanaa Abd El-Hamid HagagRadiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo, Egypt.
Mohammed Hussein AwwadZoology Department, Faculty of Science, Benha University, Banha, Egypt.
Egyptian Atomic Energy Authority · EGBenha University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a tough opponent. HCC contributes to 14.8% of all cancer mortality in Egypt. There are many choices for management of HCC; however tumor relapse has been reported in animal and clinical studies. This study was conducted to investigate the impact of low dose γ-irradiation (LDR) and combretastatin A-4 disodium phosphate (CA-4DP) on HCC recurrence. HCC was induced in male Wistar albino rats by oral administration of N-nitrosodiethylamine (NDEA) for 17 weeks. We evaluated the expression of the endothelial cell marker (CD31) by immunostaining. Expression of Rho Associated Coiled-Coil Containing Protein Kinase 1(ROCK1) and Vascular endothelial growth factor (VEGF) expression was assessed by real-time PCR after (6, 24 and 48 h). Our results showed that expression of CD31 and gene expression of ROCK1 and VEGF was significantly repressed at all-time intervals by combination therapy ofLDR and CA-4DP as compared with untreated NDEA/HCC group and NDEA/HCC groups treated with either LDR or CA-4DP alone, (P < 0.05). Our study demonstrated the additive effect of LDR in combination with CA-4DP in suppression of HCC.

Indexed as

AnimalsAntineoplastic Agents, PhytogenicCarcinoma, HepatocellularChemoradiotherapyCombined Modality TherapyDiethylnitrosamineDown-RegulationEgyptGamma RaysGene Expression Regulation, NeoplasticLiver NeoplasmsMalePlatelet Endothelial Cell Adhesion Molecule-1RatsRats, Wistarrho-Associated KinasesAntineoplastic Agents, PhytogenicDiethylnitrosaminefosbretabulinPlatelet Endothelial Cell Adhesion Molecule-1rho-Associated KinasesROCK1 protein, ratStilbenesVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratCombretastatin A-4 disodium phosphateHepatocellular carcinomaLow dose γ-irradiationROCK1VEGF

Identifiers

PMID32016634
OpenAlexW3004227794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.