ArticleActa neurochirurgica2020
The burden of headache following aneurysmal subarachnoid hemorrhage: a prospective single-center cross-sectional analysis.
Article in Acta neurochirurgica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Dot Phrase Utilization and Opioid Prescription at Discharge for Subarachnoid Hemorrhage Patients.The Neurohospitalist · 2026Article
- Early Markers of Systemic Inflammation are not Related to Pain Burden After Aneurysmal Subarachnoid Hemorrhage: A Multicenter Observational Study.Neurocritical care · 2026Observational
- Pain Management in Aneurysmatic Subarachnoid Haemorrhage: A Survey of Nordic Physicians.Acta anaesthesiologica Scandinavica · 2026Article
- Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor.Headache · 2026Article
- Headache After Stroke: An Update for the Clinician.Current neurology and neuroscience reports · 2025Review
- A Propensity Score-Weighted Analysis of Short-Term Corticosteroid Therapy for Refractory Pain Following Spontaneous Subarachnoid Hemorrhage.Neurocritical care · 2025Article
- Article
- Erenumab in a patient with persistent headaches after subarachnoid hemorrhage: A case report of an effective treatment.Headache · 2025Article
- Headache Management in the Neuroscience Intensive Care Unit.Current pain and headache reports · 2024Review
- Secondary headaches - red and green flags and their significance for diagnostics.eNeurologicalSci · 2023Review
- Acute Headache Management for Patients with Subarachnoid Hemorrhage: An International Survey of Health Care Providers.Neurocritical care · 2023Article
- Safety and efficacy of peripheral nerve blocks to treat refractory headaches after aneurysmal subarachnoid hemorrhage - A pilot observational study.Frontiers in neurology · 2023Article
- Long-term fatigue following aneurysmal subarachnoid haemorrhage and the impact on employment.European journal of neurology · 2022Observational
- Association of rareAnnals of translational medicine · 2022Article
- Duration and characteristics of persistent headache following aneurysmal subarachnoid hemorrhage.Headache · 2022Article
- Pain Control and Anxiolysis After Subarachnoid Hemorrhage Using Immersive Virtual Reality: A Case Report.The Neurohospitalist · 2022Article
- Severe headache trajectory following aneurysmal subarachnoid hemorrhage: the association with lower sodium levels.Brain injury · 2022Article
- Cerebrospinal fluid metabolic profiling reveals divergent modulation of pentose phosphate pathway by midazolam, propofol and dexmedetomidine in patients with subarachnoid hemorrhage: a cohort study.BMC anesthesiology · 2022Observational
- The endogenous neuropeptide calcitonin gene-related peptide after spontaneous subarachnoid hemorrhage-A potential psychoactive prognostic serum biomarker of pain-associated neuropsychological symptoms.Frontiers in neurology · 2022Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAneurysmal subarachnoid hemorrhage (SAH) as a serious type of stroke is frequently accompanied by a so-called initial thunderclap headache. However, the occurrence of burdensome long-term headache following SAH has never been studied in detail so far. The aim of this study was to determine the prevalence and characteristics of long-term burdensome headache in good-grade SAH patients as well as its relation to health-related quality of life (HR-QOL).
methodsAll SAH cases treated between January 2014 and December 2016 with preserved consciousness at hospital discharge were prospectively interviewed regarding burdensome headache in 2018. Study participants were subsequently scrutinized by means of a standardized postal survey comprising validated pain and HR-QOL questionnaires. A retrospective chart review provided data on the initial treatment.
resultsA total of 93 out of 145 eligible SAH patients participated in the study (62 females). A total of 41% (38/93) of subjects indicated burdensome headache at follow-up (mean 32.6 ± 9.3 months). Comparison between patients with (HA+) and without long-term headache (HA-) revealed significantly younger mean age (47.9 ± 11.8 vs. 55.6 ± 10.3 years; p < .01) as well as more favorable neurological conditions (WFNS I/II: 95% vs. 75%; p = .03) in HA+ cases. The mean average headache of the HA+ group was 3.7 ± 2.3 (10-point numeric rating scale), and the mean maximum headache intensity was 5.7 ± 2.9. Pain and HR-QOL scores demonstrated profound alterations in HA+ compared to HA- patients.
conclusionsOur results suggest that a considerable proportion of SAH patients suffers from burdensome headache even years after the hemorrhage. Moreover, long-term headache is associated with reduced HR-QOL in these cases.
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