Evidence map›Paper›PMID 32016495›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2020

Model-based calculation of thyroid gland normal tissue complication probability in head and neck cancer patients after radiation therapy.

Ivana Kinclová, Eva Hajtmanová, Pavol Matula, Soňa Balentová, Peter Muríň, Marián Ďuroška, Katarína Kozlíková

Abstract read
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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Total body irradiation as part of conditioning regimens in childhood leukemia-long-term outcome, toxicity, and secondary malignancies.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ivana KinclováOncology Centre of Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava and Martin University Hospital, Kollárova 2, 03659, Martin, Slovakia. kinclova@unm.sk.ORCID http://orcid.org/0000-0003-4334-5431
Eva HajtmanováOncology Centre of Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava and Martin University Hospital, Kollárova 2, 03659, Martin, Slovakia.
Pavol MatulaEast Slovak Oncology Institute, Inc., Rastislavova 43, 04191, Košice, Slovakia.
Soňa BalentováInstitute of Histology and Embryology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 03601, Martin, Slovakia.
Peter MuríňOncology Centre of Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava and Martin University Hospital, Kollárova 2, 03659, Martin, Slovakia.
Marián ĎuroškaOncology Centre of Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava and Martin University Hospital, Kollárova 2, 03659, Martin, Slovakia.
Katarína KozlíkováInstitute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 2, 81372, Bratislava, Slovakia.
Martin University Hospital · SKComenius University Bratislava · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPrimary hypothyroidism is one of the late complications that can occur after radiation therapy for malignant tumors in the head and neck region. The aim of this retrospective study was to show the validity of the Lyman-Kutcher-Burman (LKB) normal tissue complication model for thyroid gland based on clinical results.

methodsThyroid function was evaluated by measuring thyroid-stimulating hormone and free thyroxine serum levels before radiation therapy, 3 months after the beginning of radiation therapy, and afterwards at each follow-up visit. Cumulative incidence was calculated using the Kaplan-Meier method. Dose-volume histogram, total dose, fractionation schedule, total duration of the treatment, and other parameters were used for normal tissue complication probability calculation based on the LKB model. The model was evaluated after fitting with the three sets of parameters for grade 2 hypothyroidism: 1) "Emami," where n = 0.22; m = 0.26, and D

conclusionEmpirically based modelling of normal tissue complication probability was valid for our cohort of patients. With carefully chosen parameters, the LKB model can be used for predicting the normal tissue complication probability value.

Indexed as

Models, BiologicalAdultAgedAlgorithmsCarcinoma, Squamous CellDose Fractionation, RadiationDose-Response Relationship, RadiationFemaleHead and Neck NeoplasmsHumansHypothyroidismIncidenceMaleMiddle AgedOrgans at RiskPituitary GlandThyrotropinThyroxineHead and neck cancerHypothyroidismLyman–Kutcher–Burman modelNormal tissue complication probabilityVolumetric modulated arc therapy

Identifiers

PMID32016495
OpenAlexW3004909177

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.