ArticleMolecular medicine reports2020
Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice.
Article in Molecular medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 97 citations in OpenAlex.
- Article
- Modified Shen Ling Bai Zhu San Combined with Its Essential Oil Regulates Growth Performance, Lipid Metabolism and Intestinal Health in Silky Fowls.Animals : an open access journal from MDPI · 2026Article
- High-fat diet feeding induces organ-specific vascular remodeling with distinct temporal dynamics in male mice.Communications biology · 2026Article
- Portulaca oleracea L. extract repairs chicken cecal barrier damage caused by Eimeria tenella.Poultry science · 2026Article
- Sibutramine high-doses effects in cafeteria diet-induced obese rats.Scientific reports · 2026Article
- Targeting the intestinal barrier with traditional Chinese medicine for non-alcoholic fatty liver disease: mechanistic insights and therapeutic perspectives.Chinese medicine · 2026Review
- Global Trends in Research of Intestinal Cells and Type 2 Diabetes Mellitus: A Bibliometric and Visualized Analysis from 2004 to 2023.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation.Development, growth & differentiation · 2026Review
- The Gut Nexus: Unraveling Microbiota-Mediated Links Between Type 2 Diabetes and Colorectal Cancer.Nutrients · 2025Review
- Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet.Molecular neurobiology · 2025Article
- Microbes and diet reshape the intestine via distinct cellular dynamics.bioRxiv : the preprint server for biology · 2025Article
- Extracellular Vesicle-Like Nanoparticles Present in Fermented Botanical Products Suppress Fat Absorption in the Gut.Journal of food science · 2025Article
- Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice.Aging and disease · 2025Article
- Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation.Frontiers in pharmacology · 2025Article
- Oral administration of the probiotic strainFrontiers in pharmacology · 2025Article
- The epigenetic influence of diet-induced gut microbiome changes in precision nutrition - a systematic review.Gastroenterology and hepatology from bed to bench · 2025Review
- Pharmacological potential of endocannabinoid and endocannabinoid-like compounds in protecting intestinal structure and metabolism under high-fat conditions.Frontiers in pharmacology · 2025Review
- Epithelial barrier hypothesis in the context of nutrition, microbial dysbiosis, and immune dysregulation in metabolic dysfunction-associated steatotic liver.Frontiers in immunology · 2025Review
- Article
- Deleterious Effects of Yoyo Dieting and Resistant Starch on Gastrointestinal Morphology.Nutrients · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high‑fat diet (HFD) or obesity‑promoting diet is closely associated with metabolic diseases and intestinal tumors, particularly in middle‑aged individuals (typically 45‑64 years old). The intestinal epithelium constitutes a barrier that separates the host from the food and microbiota in the gut, and thus, a dysfunctional epithelium is associated with a number of diseases. However, the changes caused to the function of intestinal epithelium in response to an HFD have not been well‑studied to date. In the present study, middle‑aged female mice (12 months old) fed an HFD for a period of 14 weeks were used to determine the effects of HFD on the intestine. Characteristics including the body weight, fat deposition, glucose metabolism, inflammatory state and intestinal morphology were assessed, while the intestinal stem cell (ISC) counts and the ability of isolated intestinal crypts to form organoid bodies in 3D culture were examined. Intestinal epithelial barrier function, including secretory defense, tight junctions and cell apoptosis, were also studied. Morphologically, the HFD resulted in a mild reduction in the length of villi of the small intestine, the colon length and the depth of colon crypts. In addition, the ISC counts were increased in the small intestine and colon in HFD‑fed mice. The ability of crypts to grow into organoids (mini‑guts) was also increased in crypts obtained from mice fed an HFD, while HFD compromised the epithelial barrier function of the colon. These results demonstrated how an HFD affects the intestinal epithelium and highlighted the need to carefully consider dietary patterns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.