ArticleSchizophrenia bulletin2020
Connectomic Underpinnings of Working Memory Deficits in Schizophrenia: Evidence From a replication fMRI study.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Investigating functional brain networks in multiple sclerosis patients: a graph theory approach for evaluating working memory impairment.Brain informatics · 2026Article
- Age of Onset, Brain Controllability, and Working Memory Performance in First-Episode Schizophrenia.Schizophrenia bulletin · 2026Article
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Effects of electroconvulsive therapy on functional brain networks in patients with schizophrenia.BMC psychiatry · 2024Article
- Aberrant Brain Dynamics in Schizophrenia During Working Memory Task: Evidence From a Replication Functional MRI Study.Schizophrenia bulletin · 2024Article
- Automatic diagnosis of schizophrenia and attention deficit hyperactivity disorder in rs-fMRI modality using convolutional autoencoder model and interval type-2 fuzzy regression.Cognitive neurodynamics · 2023Article
- Antisocial behavior is associated with reduced frontoparietal network efficiency in youth.Social cognitive and affective neuroscience · 2023Article
- The topology, stability, and instability of learning-induced brain network repertoires in schizophrenia.Network neuroscience (Cambridge, Mass.) · 2023Article
- The centrality of working memory networks in differentiating bipolar type I depression from unipolar depression: A task-fMRI study.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Article
- Brain disease research based on functional magnetic resonance imaging data and machine learning: a review.Frontiers in neuroscience · 2023Review
- Associations between polygenic risk, negative symptoms, and functional connectome topology during a working memory task in early-onset schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Decreased integration of default-mode network during a working memory task in schizophrenia with severe attention deficits.Frontiers in cellular neuroscience · 2022Article
- Serotonin-norepinephrine reuptake inhibitor antidepressant effects on regional connectivity of the thalamus in persistent depressive disorder: evidence from two randomized, double-blind, placebo-controlled clinical trials.Brain communications · 2022Article
- Acute Effect of Betel Quid Chewing on Brain Network Dynamics: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2021Article
- Differing functional mechanisms underlie cognitive control deficits in psychotic spectrum disorders.Journal of psychiatry & neuroscience : JPN · 2020Article
- Altered brain network topology related to working memory in internet addiction.Journal of behavioral addictions · 2020Article
- Effective connectivity of the right anterior insula in schizophrenia: The salience network and task-negative to task-positive transition.NeuroImage. Clinical · 2020Article
- Load-dependent inverted U-shaped connectivity of the default mode network in schizophrenia during a working-memory task: evidence from a replication functional MRI study.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWorking memory (WM) deficit is a key feature of schizophrenia that relates to a generalized neural inefficiency of extensive brain areas. To date, it remains unknown how these distributed regions are systemically organized at the connectome level and how the disruption of such organization brings about the WM impairment seen in schizophrenia.
methodsWe used graph theory to examine the neural efficiency of the functional connectome in different granularity in 155 patients with schizophrenia and 96 healthy controls during a WM task. These analyses were repeated in another independent dataset (81 patients and 54 controls). Linear regression analysis was used to test associations of altered graph properties, clinical symptoms, and WM accuracy in patients. A machine-learning approach was adopted to study the ability of multivariate connectome features from one dataset to discriminate patients from controls in the second dataset.
resultsSmall-worldness of the whole-brain connectome was significantly increased in schizophrenia during the WM task; this increase is related to better (though subpar) WM accuracy in patients with more severe negative symptom burden. There was a shift in the degree distribution to a more homogeneous form in patients. The machine-learning approach classified a new set of patients from controls with 84.3% true-positivity rate for schizophrenia and 71.6% overall accuracy.
conclusionsWe demonstrate a putative mechanistic link between connectome topology, hub redistribution, and impaired n-back performance in schizophrenia. The task-dependent modulation of the connectome relates to, but remains inefficient in, improving the performance above par in the presence of severe negative symptoms.
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