ArticleJAAD case reports2020
Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin.
Article in JAAD case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06087796 (Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata: a Clinical and Dermoscopic Study.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Comorbidities in primary cicatricial alopecia: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Safety and clinical considerations of alopecia therapies during pregnancy, fertility treatment, and polycystic ovary syndrome workup.International journal of women's dermatology · 2026Review
- Topical Metformin Compared with Clobetasol Propionate for Alopecia Areata: Clinical Outcomes from a Comparative Study.Dermatology practical & conceptual · 2026Article
- Safety of Alopecia Treatments in Patients with Breast Cancer and High-Risk Women: A Review.American journal of clinical dermatology · 2025Review
- Compounded metformin 10%/triamcinolone 0.1%/gabapentin 6% for treatment of extragenital lichen sclerosus.JAAD case reports · 2025Article
- Article
- Adjuvant use of topical metformin with standard therapies in recalcitrant central centrifugal cicatricial alopecia: A case series.JAAD case reports · 2025Article
- A Systematic Review on Clinical Evidence for Topical Metformin: Old Medication With New Application.Health science reports · 2024Review
- Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation.JID innovations : skin science from molecules to population health · 2024Article
- Clinical factors and hair care practices influencing outcomes in central centrifugal cicatricial alopecia.Archives of dermatological research · 2023Article
- Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib.JAAD case reports · 2023Article
- The function, mechanisms, and clinical applications of metformin: potential drug, unlimited potentials.Archives of pharmacal research · 2023Review
- Τhe Endless Beauty of Metformin: Does It Also Protect from Skin Aging? A Narrative Review.Advances in therapy · 2023Review
- Unveiling a Shared Precursor Condition for Acne Keloidalis Nuchae and Primary Cicatricial Alopecias.Clinical, cosmetic and investigational dermatology · 2023Article
- Modulation of autophagy, apoptosis and oxidative stress: a clue for repurposing metformin in photoaging.Inflammopharmacology · 2022Article
- Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment.Clinical, cosmetic and investigational dermatology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.