ArticleGenes & nutrition2020
Effects of excess sugars and lipids on the growth and development of
Article in Genes & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
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- Cyclin D1 regulates the hepatic response to feeding: Evidence for non-cell cycle roles in the liver.bioRxiv : the preprint server for biology · 2026Article
- Effects of a High-Glucose Diet onACS omega · 2026Article
- Coupled transcriptome and proteome analysis of L3 and L4 developmental stages of Anisakis simplex s. s.: insights into target genes under glucose influence.BMC genomics · 2025Article
- Mapping-based genome size estimation.BMC genomics · 2025Article
- Isothiocyanate-Rich Moringa Seed Extract Activates SKN-1/Nrf2 Pathway inInternational journal of molecular sciences · 2024Article
- SKN-1/NRF2 upregulation by vitamin A is conserved from nematodes to mammals and is critical for lifespan extension in Caenorhabditis elegans.Aging cell · 2024Article
- Oleic Acid Metabolism in Response to Glucose inMetabolites · 2023Article
- Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration.BMC biology · 2023Article
- Phenolic Compounds fromMolecules (Basel, Switzerland) · 2023Article
- Antiobesity and Antioxidative Effect of Fermented Brown Rice Using In Vitro with In VivoLife (Basel, Switzerland) · 2023Article
- Energy dispersive X-Ray microanalysis in conjunction with scanning electron micrography to establish nematodes as bioindicators in marine fish environment.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Anti-Obesity Efficacy ofInternational journal of molecular sciences · 2022Article
- Effect of lifelong sucrose consumption at human-relevant levels on food intake and body composition of C57BL/6N mice.Frontiers in nutrition · 2022Article
- Review
- Random forest classification for predicting lifespan-extending chemical compounds.Scientific reports · 2021Article
- Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan.Antioxidants (Basel, Switzerland) · 2021Review
- Worms, Fat, and Death:Metabolites · 2021Review
- Molecular basis of reproductive senescence: insights from model organisms.Journal of assisted reproduction and genetics · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExcessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and complications. Here, we characterized the effects of different types of sugar and lipids on the growth and development of
methodsWe measured the lifespan, reproductive capacity, and length of nematodes after sugars and lipids treatment alone and co-treatment of sugars and lipids. Furthermore, we studied the mechanisms underlying the damage caused by high-sucrose and high-stearic acid on
resultsThe results showed that a certain concentration of sugar and lipid promoted the growth and development of nematodes. However, excessive sugars and lipids shortened the lifespan and length of nematodes and destroyed their reproductive capacity. Based on the results of the orthogonal test, we selected 400 mmol/L sucrose and 500 μg/mL stearic acid to model a high-sugar and high-lipid diet for
conclusionHigh-sugar and high-lipid intake altered the expression of genes involved in biofilm synthesis, genes that catalyze the synthesis and degradation of endogenous substances, and genes involved in innate immunity, resulting in physiological damage. Furthermore, we explored the protective effect of resveratrol on high-sugar and high-lipid damage to nematodes. Resveratrol plays a role in repairing by participating in the metabolism of foreign substances and reducing cellular oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.