Evidence map›Paper›PMID 32015507›Full record

ArticleNature2020

A pneumonia outbreak associated with a new coronavirus of probable bat origin.

Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang and 19 more

Erratum issued 23 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 23 registered trials, which are not on this map. Cited by 11,645 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11,645citing papers in PubMed, 1 pooled it
533.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04324996 phase1 / phase2unknown statusnot on this map

A Phase I/II Study of Universal Off-the-shelf NKG2D-ACE2 CAR-NK Cells Secreting IL15 Superagonist and GM-CSF-neutralizing scFv for Therapy of COVID-19

TypeinterventionalSponsorChongqing Public Health Medical CenterRan2020 to 2022Enrolled90ConditionsCOVID-19ArmsNK cells,IL15-NK cells,NKG2D CAR-NK cells,ACE2 CAR-NK cells,NKG2D-ACE2 CAR-NK cells
NCT04326036 early_phase1unknown statusnot on this map

Use of cSVF For Residual Lung Damage (COPD/Fibrotic Lung Disease After Symptomatic COVID-19 Infection For Residual Pulmonary Injury or Post-Adult Respiratory Distress Syndrome Following Viral (SARS-Co-2) Infection

TypeinterventionalSponsorBlack Tie Medical, Inc.Ran2020 to 2024Enrolled10ConditionsPulmonary Alveolar Proteinosis, COPD, Idiopathic Pulmonary Fibrosis, Viral PneumoniaArmsMicrocannula Harvest Adipose Derived tissue stromal vascular fraction (tSVF), Centricyte 1000, IV Deployment Of cSVF In Sterile Normal Saline IV Solution, Liberase Enzyme (Roche), Sterile Normal Saline for Intravenous Use
NCT04337983 completednot on this map

Hemodynamic Characteristics of Patients With SARS-CoV-2: PiCCOVID Study

TypeobservationalSponsorBicetre HospitalRan2020 to 2020Enrolled60ConditionsCoronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Distress SyndromeArmsTranspulmonary thermodilution, Echocardiography
NCT04357535 completednot on this map

Prognosis of SARS-Cov 2 Positive Patients Receiving Angiotensin Converting Enzyme Inhibitors (ACE-I) and Angiotensin II Receptor Antagonists (ARBs)

TypeobservationalSponsorHakeam Abdulaziz HakeamRan2020 to 2020Enrolled314ConditionsCOVID-19ArmsAngiotensin-Converting Enzyme Inhibitors (ACE-I) and Angiotensin II Receptor Blockers (ARB)
NCT04359797 nacompletednot on this map

Pragmatic Trial Exploring Impact of Patient Positioning in the Management of Patients Infected With COVID-19: Supine vs. Prone

TypeinterventionalSponsorVanderbilt University Medical CenterRan2020 to 2021Enrolled501ConditionsCOVID-19ArmsProne, Usual Care
NCT04372628 phase2completednot on this map

Trial of Early Therapies During Non-hospitalized Outpatient Window (TREAT NOW) for COVID-19

TypeinterventionalSponsorVanderbilt University Medical CenterRan2020 to 2022Enrolled452ConditionsCOVID-19ArmsLopinavir/Ritonavir 400 mg/100 mg, Placebo
NCT04374149 phase2completednot on this map

Interventional Study to Evaluate the Efficacy of Therapeutic Plasma Exchange (TPE) Alone or in Combination With Ruxolitinib in COVID-19 Positive Patients With PENN Grade 2, 3, 4 Cytokine Released Syndrome (CRS)

TypeinterventionalSponsorPrisma Health-UpstateRan2020 to 2020Enrolled20ConditionsCytokine Release Syndrome, COVID19ArmsTherapeutic Plasma Exchange, Ruxolitinib
NCT04374838 unknown statusnot on this map

Effect of COVID-19 Pandemic on Pediatric Cancer Care

TypeobservationalSponsorSouth Egypt Cancer InstituteRan2020 to 2021Enrolled20ConditionsCovid19
NCT04380870 unknown statusnot on this map

Describing Chinese Herbal Medicine Telehealth Care for Symptoms Related to Infectious Diseases Such as COVID-19: A Descriptive, Longitudinal, Pragmatic Cohort Study

TypeobservationalSponsorCenter for Integrated CareRan2020 to 2025Enrolled500ConditionsCoronavirus InfectionArmsChinese Herbal Medicine
NCT04420260 nacompletednot on this mapstarted 2021, after this paper: background citation

Scheme of Primary Prevention of Infection by COVID-19, in Workers: Phase II Controlled Clinical Trial, to be Carried Out in Medellín-Antioquia

TypeinterventionalSponsorUnidad de Investigación Genética MolecularRan2021 to 2021Enrolled152ConditionsCOVIDArmsGroup A: oropharygeal spray and immunostimulant emulsion, Group D:Placebo oropharyngeal spray + Placebo taken PO
NCT04432103 phase3terminatednot on this map

Treatment of Severe and Critical COVID-19 Pneumonia With Convalescent Plasma

TypeinterventionalSponsorCentro Medico ABCRan2020 to 2021Enrolled6ConditionsCovid-19ArmsAnti SARS-CoV 2 Convalescent Plasma in severe COVID-19 patients, Anti SARS-CoV 2 Convalescent Plasma in critical COVID-19 patients
NCT04465552 completednot on this map

Arrhythmic Manifestations and Management Strategies in Hospitalized COVID-19 Patients: Proposal for a Multicenter Registry

TypeobservationalSponsorKansas City Heart Rhythm Research FoundationRan2020 to 2021Enrolled666ConditionsCoronavirus InfectionsArmsPatients received standard of care treatment during hospitalization
NCT04516746 phase3completednot on this map

A Phase III Randomized, Double-blind, Placebo-controlled Multicenter Study in Adults, to Determine the Safety, Efficacy, and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, for the Prevention of COVID-19

TypeinterventionalSponsorAstraZenecaRan2020 to 2023Enrolled32,450ConditionsCOVID-19, SARS-CoV-2ArmsAZD1222, Placebo
NCT04533347 phase2completednot on this mapstarted 2021, after this paper: background citation

A Double-blind Placebo-controlled Study to Assess the Efficacy and Safety of Oral Tafenoquine Versus Placebo in Patients With Mild to Moderate COVID-19 Disease

TypeinterventionalSponsor60 Degrees Pharmaceuticals LLCRan2021 to 2022Enrolled86ConditionsCOVID 19 DiseaseArmsTafenoquine Oral Tablet, Placebo
NCT04548557 phase3unknown statusnot on this map

Intravenous Immunoglobulins for the Treatment of Covid-19 Patients: a Clinical Trial

TypeinterventionalSponsorUniversity of Health Sciences LahoreRan2020 to 2020Enrolled60ConditionsCovid19Armsintravenous immunoglobulin therapy
NCT04598334 unknown statusnot on this mapstarted 2022, after this paper: background citation

Investigating the Inflammatory Cytokines and Cytokine Storm Among Bangladeshi Patients With COVID-19: a Prospective, Observational Study

TypeobservationalSponsorInternational Centre for Diarrhoeal Disease Research, BangladeshRan2022 to 2022Enrolled75ConditionsCytokine Storm, COVID-19
NCT04625725 phase3completednot on this map

A Phase III Randomized, Double-blind, Placebo-controlled, Multi-center Study in Adults to Determine the Safety and Efficacy of AZD7442, a Combination Product of Two Monoclonal Antibodies (AZD8895 and AZD1061), for Pre-exposure Prophylaxis of COVID-19.

TypeinterventionalSponsorAstraZenecaRan2020 to 2023Enrolled5,197ConditionsCOVID-19ArmsAZD7442, Placebo
NCT04625972 phase3completednot on this map

A Phase III Randomized, Double-blind, Placebo-controlled, Multi-center Study in Adults to Determine the Safety and Efficacy of AZD7442, a Combination Product of Two Monoclonal Antibodies (AZD8895 and AZD1061), for Post-exposure Prophylaxis of COVID-19

TypeinterventionalSponsorAstraZenecaRan2020 to 2022Enrolled1,131ConditionsCOVID-19ArmsAZD7442, Placebo
NCT04640038 phase3completednot on this map

Contrast Enhanced Ultrasound (CEUS) Detection of Microvascular Perfusion Impairment in COVID-19 Pediatric Patients

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2020 to 2021Enrolled4ConditionsCovid19, Multisystem Inflammatory Syndrome in Children (MIS-C)ArmsSulfur hexafluoride lipid-type A microspheres
NCT04723394 phase3completednot on this mapstarted 2021, after this paper: background citation

A Phase III Randomized, Double-blind, Placebo-controlled, Multicenter Study to Determine the Safety and Efficacy of AZD7442 for the Treatment of COVID-19 in Non-hospitalized Adults

TypeinterventionalSponsorAstraZenecaRan2021 to 2022Enrolled910ConditionsCOVID-19ArmsAZD7442, Placebo
NCT04861402 completednot on this map

Non-Invasive Intracranial Pressure in COVID-19 Individuals

TypeobservationalSponsorFederal University of São PauloRan2020 to 2021Enrolled60ConditionsIntracranial PressureArmsThe ICP monitoring will be performed in a non-invasive method developed by Brain4Care
NCT04914832 phase4completednot on this mapstarted 2021, after this paper: background citation

Effectiveness of Covid-19 Vaccination in Eswatini Against SARS-CoV-2 Associated Hospitalization and Death

TypeinterventionalSponsorShabir MadhiRan2021 to 2022Enrolled75,012ConditionsCOVID-19, Pneumonia, ViralArmsAZD1222
NCT05060354 completednot on this mapstarted 2021, after this paper: background citation

Immune Response to SARS-CoV2 Vaccinations in Treated MS Patients Compared to Controls

TypeobservationalSponsorBrigham and Women's HospitalRan2021 to 2023Enrolled159ConditionsMultiple Sclerosis, HealthyArmsBlood draw
3 · Its place in the literature

Who cites it

11,645 citing papers in PubMed, 1 synthesis or guideline pooled it, 23,190 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Article
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  13. Wildlife Trade and Genetic Basis of Disease Susceptibility: A Review.International journal of immunogenetics · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Novel AfricanJournal of virology · 2026
    Article
  19. Article
  20. Article

11,585 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 5 institutions in 1 country.

Peng Zhou *CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Xing-Lou Yang *CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Xian-Guang Wang *Wuhan Jin Yin-Tan Hospital, Wuhan, China.
Ben HuCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Lei ZhangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Wei ZhangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Hao-Rui SiCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yan ZhuCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Bei LiCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Chao-Lin HuangWuhan Jin Yin-Tan Hospital, Wuhan, China.
Hui-Dong ChenWuhan Jin Yin-Tan Hospital, Wuhan, China.
Jing ChenCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yun LuoCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Hua GuoCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Ren-Di JiangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Mei-Qin LiuCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Ying ChenCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Xu-Rui ShenCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Xi WangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Xiao-Shuang ZhengCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Kai ZhaoCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Quan-Jiao ChenCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Fei DengCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Lin-Lin LiuHubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Bing YanCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Fa-Xian ZhanHubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Yan-Yi WangCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Geng-Fu XiaoCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Zheng-Li ShiCAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.
Wuhan Institute of Virology · CNChinese Academy of Sciences · CNWuhan City Chinese Medicine Hospital · CNHubei Provincial Center for Disease Control and Prevention · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats

Indexed as

Disease OutbreaksAngiotensin-Converting Enzyme 2AnimalsAntibodies, ViralBetacoronavirusCell LineChinaChiropteraChlorocebus aethiopsCoronavirus InfectionsCOVID-19FemaleGenome, ViralHumansMalePeptidyl-Dipeptidase AACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, ViralPeptidyl-Dipeptidase A

Identifiers

PMID32015507
PMCPMC7095418
OpenAlexW3004280078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

and 17 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.