Evidence map›Paper›PMID 32015461›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020

Double blind, two dose, randomized, placebo-controlled, cross-over clinical trial of the positive allosteric modulator at the alpha7 nicotinic cholinergic receptor AVL-3288 in schizophrenia patients.

Joshua T Kantrowitz, Daniel C Javitt, Robert Freedman, Pejman Sehatpour, Lawrence S Kegeles, Marlene Carlson, Tarek Sobeih, Melanie M Wall, Tse-Hwei Choo, Blair Vail and 2 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
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  19. The Role of fMRI in Drug Development: An Update.Advances in neurobiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Joshua T KantrowitzColumbia University, New York, USA. jk3380@cumc.columbia.edu.
Daniel C JavittColumbia University, New York, USA.
Robert FreedmanU Colorado, Denver, CO, USA.ORCID http://orcid.org/0000-0002-2181-2898
Pejman SehatpourColumbia University, New York, USA.
Lawrence S KegelesColumbia University, New York, USA.
Marlene CarlsonColumbia University, New York, USA.
Tarek SobeihNathan Kline Institute, Orangeburg, USA.
Melanie M WallColumbia University, New York, USA.
Tse-Hwei ChooColumbia University, New York, USA.
Blair VailNew York State Psychiatric Institute, New York, USA.
Jack GrinbandColumbia University, New York, USA.
Jeffrey A LiebermanColumbia University, New York, USA.
New York State Psychiatric InstituteNathan Kline Institute for Psychiatric Research · US

Funding

Human Trial of Allosteric Modulator Alpha7 Nicotinic Receptors in SchizophreniaU01MH094247 · NIMH · UNIVERSITY OF COLORADO DENVER · PI KANTROWITZ, JOSHUA TOLKIEN, LIEBERMAN, JEFFREY A. · 2011 to 2015
$7.5M
NIMH NIH HHS U01 MH094247
6 · The paper itself

Abstract

Despite their theoretical rationale, nicotinic alpha-7 acetylcholine (nα

Indexed as

Antipsychotic AgentsPsychotic DisordersSchizophreniaalpha7 Nicotinic Acetylcholine ReceptorCross-Over StudiesDouble-Blind MethodHumansPsychiatric Status Rating ScalesTreatment Outcomealpha7 Nicotinic Acetylcholine ReceptorAntipsychotic Agents

Identifiers

PMID32015461
PMCPMC7298033
OpenAlexW3003669298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.