Evidence map›Paper›PMID 32015442›Full record

ArticleScientific reports2020

Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca

Lisann Pelzl, Itishri Sahu, Ke Ma, David Heinzmann, Abdulla Al Mamun Bhuyan, Tamer Al-Maghout, Basma Sukkar, Yamini Sharma, Irene Marini, Flaviana Rigoni and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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  6. Effect of MgClInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Lisann Pelzl *Transfusion Medicine, Medical Faculty, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Itishri Sahu *Department of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Ke MaDepartment of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.ORCID http://orcid.org/0000-0002-9077-918X
David HeinzmannDepartment of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Abdulla Al Mamun BhuyanDepartment of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Tamer Al-MaghoutDepartment of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Basma SukkarDepartment of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.ORCID http://orcid.org/0000-0003-4945-9333
Yamini SharmaDepartment of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Irene MariniTransfusion Medicine, Medical Faculty, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Flaviana RigoniTransfusion Medicine, Medical Faculty, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Ferruh ArtuncDepartment of Internal Medicine IV, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Hang CaoDepartment of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Ravi GuttiDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.ORCID http://orcid.org/0000-0002-0912-5796
Jakob VoelklInstitute for Physiology, Johannes Kepler University, Linz, Austria.
Burkert PieskeDZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Meinrad GawazDepartment of Internal Medicine III, Eberhard Karl University Tuebingen, Tuebingen, Germany.ORCID http://orcid.org/0000-0003-1124-9592
Tamam BakchoulTransfusion Medicine, Medical Faculty, Eberhard Karl University Tuebingen, Tuebingen, Germany.ORCID http://orcid.org/0000-0002-6797-6812
Florian LangDepartment of Vegetative and Clinical Physiology, Eberhard Karl University Tuebingen, Tuebingen, Germany. florian.lang@uni-tuebingen.de.ORCID http://orcid.org/0000-0003-2962-1540
University of Tübingen · DEUniversity of Hyderabad · INGerman Centre for Cardiovascular Research · DEJohannes Kepler University of Linz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impairment of renal phosphate elimination in chronic kidney disease (CKD) leads to enhanced plasma and tissue phosphate concentration, which in turn up-regulates transcription factor NFAT5 and serum & glucocorticoid-inducible kinase SGK1. The kinase upregulates ORAI1, a Ca

Indexed as

AgedBlood PlateletsCalciumCells, CulturedFemaleGlycerophosphatesHumansImmediate-Early ProteinsKidneyMaleMegakaryocytesMiddle AgedNFATC Transcription FactorsORAI1 ProteinProtein Serine-Threonine KinasesRenal Insufficiency, Chronicbeta-glycerophosphoric acidCalciumGlycerophosphatesImmediate-Early ProteinsNFATC Transcription FactorsORAI1 ProteinORAI1 protein, humanProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated KinasesStromal Interaction Molecule 1Stromal Interaction Molecule 2

Identifiers

PMID32015442
PMCPMC6997179
OpenAlexW3004720106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.