ArticleScientific reports2020
Improved Calcium Homeostasis and Force by Selenium Treatment and Training in Aged Mouse Skeletal Muscle.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Matcha green tea beverage moderates fatigue and supports resistance training-induced adaptation.Nutrition journal · 2023Trial
- Selenium Deficiency is a Significant Risk Factor for Sarcopenia: Evidence and Selenoprotein-Mediated Mechanisms.Biological trace element research · 2026Review
- TNFR1 signaling connects inflammation to impaired fatty acid oxidation to drive intestinal stem cell aging.Nature aging · 2026Article
- Selenium-Biofortified Probiotics: A Synergistic Microbial-Nutritional Strategy Against Exercise-Induced Stress.Nutrients · 2026Review
- Association between nutrient patterns and muscle mass, fat mass, and BMI among Iranian adolescents: a cross-sectional study.BMC public health · 2026Article
- Multimechanistic actions of functional factors in enhancing physical strength and endurance: a scoping review of nutritional basis and natural extracts.Frontiers in sports and active living · 2026Review
- Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS-NADPH Dysregulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- Low Selenium Diet Inhibited CaMKII Activation via miR-365-3p/SelT Signaling Axis, Resulting in Myoblast Differentiation Disorders and Skeletal Muscle Damage in Broilers.Biological trace element research · 2025Article
- Article
- Aging in the Skeletal Muscle Revealed by Molecular Immunohistochemical Imaging.International journal of molecular sciences · 2025Review
- Selenium and Skeletal Muscle Health in Sports Nutrition.Nutrients · 2025Review
- Reversing Decline in Aging Muscles: Expected Trends, Impacts and Remedies.Journal of functional morphology and kinesiology · 2025Review
- Review
- Loss of SELENOW aggravates muscle loss with regulation of protein synthesis and the ubiquitin-proteasome system.Science advances · 2024Article
- Impaired Upper Airway Muscle Function with Excessive or Deficient Dietary Intake of Selenium in Rats.Antioxidants (Basel, Switzerland) · 2024Article
- Ablation of skeletal muscle estrogen receptor alpha impairs contractility in male mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The Effects of Aging on Sarcoplasmic Reticulum-Related Factors in the Skeletal Muscle of Mice.International journal of molecular sciences · 2024Article
- Branched-chain amino acids and L-alanine supplementation ameliorate calcium dyshomeostasis in sarcopenia: New insights for nutritional interventions.Frontiers in pharmacology · 2024Article
- Understanding altered contractile properties in advanced age: insights from a systematic muscle modelling approach.Biomechanics and modeling in mechanobiology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During aging reduction in muscle mass (sarcopenia) and decrease in physical activity lead to partial loss of muscle force and increased fatigability. Deficiency in the essential trace element selenium might augment these symptoms as it can cause muscle pain, fatigue, and proximal weakness. Average voluntary daily running, maximal twitch and tetanic force, and calcium release from the sarcoplasmic reticulum (SR) decreased while reactive oxygen species (ROS) production associated with tetanic contractions increased in aged - 22-month-old - as compared to young - 4-month-old - mice. These changes were accompanied by a decline in the ryanodine receptor type 1 (RyR1) and Selenoprotein N content and the increased amount of a degraded RyR1. Both lifelong training and selenium supplementation, but not the presence of an increased muscle mass at young age, were able to compensate for the reduction in muscle force and SR calcium release with age. Selenium supplementation was also able to significantly enhance the Selenoprotein N levels in aged mice. Our results describe, for the first time, the beneficial effects of selenium supplementation on calcium release from the SR and muscle force in old age while point out that increased muscle mass does not improve physical performance with aging.
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