Evidence map›Paper›PMID 32015409›Full record

ArticleNature biomedical engineering2020

Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties.

Guosheng Song, Michael Kenney, Yun-Sheng Chen, Xianchuang Zheng, Yong Deng, Zhuo Chen, Shan X Wang, Sanjiv Sam Gambhir, Hongjie Dai, Jianghong Rao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 250 citations in OpenAlex.

  1. Review
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  4. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
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  6. Spatiotemporal cancer controlNanomedicine (London, England) · 2026
    Review
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  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Guosheng SongState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China. songgs@hnu.edu.cn.ORCID http://orcid.org/0000-0001-5628-6245
Michael KenneyDepartment of Chemistry and Bio-X, Stanford University, Stanford, CA, USA.
Yun-Sheng ChenMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, Stanford, CA, USA.
Xianchuang ZhengMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, Stanford, CA, USA.
Yong DengDepartments of Electrical Engineering and Materials Sciences and Engineering, Stanford University, Stanford, CA, USA.
Zhuo ChenState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Shan X WangDepartments of Electrical Engineering and Materials Sciences and Engineering, Stanford University, Stanford, CA, USA.
Sanjiv Sam GambhirMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2711-7554
Hongjie DaiDepartment of Chemistry and Bio-X, Stanford University, Stanford, CA, USA.
Jianghong RaoMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, Stanford, CA, USA. jrao@stanford.edu.ORCID http://orcid.org/0000-0002-5143-9529
Stanford University · USHunan University · CNStanford Medicine · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2015 to 2019
$9.6M
NCI NIH HHS U54 CA199075
6 · The paper itself

Abstract

The low magnetic saturation of iron oxide nanoparticles, which are developed primarily as contrast agents for magnetic resonance imaging, limits the sensitivity of their detection using magnetic particle imaging (MPI). Here, we show that FeCo nanoparticles that have a core diameter of 10 nm and bear a graphitic carbon shell decorated with poly(ethylene glycol) provide an MPI signal intensity that is sixfold and fifteenfold higher than the signals from the superparamagnetic iron oxide tracers VivoTrax and Feraheme, respectively, at the same molar concentration of iron. We also show that the nanoparticles have photothermal and magnetothermal properties and can therefore be used for tumour ablation in mice, and that they have high optical absorbance in a broad near-infrared region spectral range (wavelength, 700-1,200 nm), making them suitable as tracers for photoacoustic imaging. As sensitive multifunctional and multimodal imaging tracers, carbon-coated FeCo nanoparticles may confer advantages in cancer imaging and hyperthermia therapy.

Indexed as

AnimalsBreast NeoplasmsCarbonContrast MediaDiagnostic ImagingDisease Models, AnimalFemaleFerric CompoundsHeterograftsHyperthermia, InducedMagnetic Resonance ImagingMagneticsMiceMice, Inbred BALB CMice, NudeNanoparticlesCarbonContrast MediaFerric Compoundsferric oxidePolyethylene Glycols

Identifiers

PMID32015409
PMCPMC7071985
OpenAlexW3005376409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.