ArticleNature biomedical engineering2020
Rapid optofluidic detection of biomarkers for traumatic brain injury via surface-enhanced Raman spectroscopy.
Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Pooled it
- SERSome-based metabolic profiling of aqueous humor for cataract subtyping with molecule-level interpretability.Journal of nanobiotechnology · 2026Article
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- Wireless In Situ Catalytic Electron Signaling-Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Emerging Technologies for Timely Point-of-Care Diagnostics of Skin Cancer.Global challenges (Hoboken, NJ) · 2025Review
- Gold nanoparticle decorated flexible carbon cloth for sensitive detection of 2, 6-pyridine dicarboxylic acid by surface-enhanced Raman scattering.Biomedical optics express · 2025Article
- Integration of Nanoengineering with Artificial Intelligence and Machine Learning in Surface-Enhanced Raman Spectroscopy (SERS) for the Development of Advanced Biosensing Platforms.Advanced sensor research · 2025Article
- Random splicing assisted deep learning for breast cancer cell line classification via Raman spectroscopy.Computational and structural biotechnology journal · 2025Article
- Review
- Serum exosomes miR-206 and miR-549a-3p as potential biomarkers of traumatic brain injury.Scientific reports · 2024Article
- 'When is a hotspot a good nanospot' - review of analytical and hotspot-dominated surface enhanced Raman spectroscopy nanoplatforms.Nanoscale · 2024Review
- Nano-Plumber Reshapes Glymphatic-Lymphatic System to Sustain Microenvironment Homeostasis and Improve Long-Term Prognosis after Traumatic Brain Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic.Science advances · 2023Article
- Article
- Recent Advances in Metaphotonic Biosensors.Biosensors · 2023Review
- Surface-Enhanced Raman Analysis of Uric Acid and Hypoxanthine Analysis in Fractionated Bodily Fluids.Nanomaterials (Basel, Switzerland) · 2023Article
- Ultraminiaturized Microfluidic Electrochemical Surface-Enhanced Raman Scattering Chip for Analysis of Neurotransmitters Fabricated by Ship-in-a-Bottle Integration.Small science · 2023Article
- Raman Spectroscopy as a Tool to Study the Pathophysiology of Brain Diseases.International journal of molecular sciences · 2023Review
- Rapid, label-free histopathological diagnosis of liver cancer based on Raman spectroscopy and deep learning.Nature communications · 2023Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Current technologies for the point-of-care diagnosis of traumatic brain injury (TBI) lack sensitivity, require specialist handling or involve complicated and costly procedures. Here, we report the development and testing of an optofluidic device for the rapid and label-free detection, via surface-enhanced Raman scattering (SERS), of picomolar concentrations of biomarkers for TBI in biofluids. The SERS-active substrate of the device consists of electrohydrodynamically fabricated submicrometre pillars covered with a plasmon-active nanometric gold layer, integrated in an optofluidic chip. We show that the device can detect N-acetylasparate in finger-prick blood samples from patients with TBI, and that the biomarker is released immediately from the central nervous system after TBI. The simplicity, sensitivity and robustness of SERS-integrated optofluidic technology might eventually help the triaging of TBI patients and assist clinical decision making at point-of-care settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.