ArticleScientific reports2020
Quantitative spatio-temporal characterization of epileptic spikes using high density EEG: Differences between NREM sleep and REM sleep.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Can REM Sleep Localize the Epileptogenic Zone? A Systematic Review and Analysis.Frontiers in neurology · 2020Pooled it
- Sleep increases firing rate modulation during interictal epileptiform discharges in mesial temporal structures.Brain communications · 2026Article
- Mechanistic insights into the interaction between epilepsy and sleep.Nature reviews. Neurology · 2025Review
- Dreams interrupted: characteristics of REM sleep-associated seizures and status epilepticus.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Influence of sleep on seizures and interictal epileptiform discharges in epilepsy.Encephalitis (Seoul, Korea) · 2025Article
- Article
- Timing Mechanisms for Circadian Seizures.Clocks & sleep · 2024Review
- Consistency of electrical source imaging in presurgical evaluation of epilepsy across different vigilance states.Annals of clinical and translational neurology · 2024Article
- Sleep, oscillations, and epilepsy.Epilepsia · 2023Article
- Unsupervised Multitaper Spectral Method for Identifying REM Sleep in Intracranial EEG Recordings Lacking EOG/EMG Data.Bioengineering (Basel, Switzerland) · 2023Article
- Spike patterns surrounding sleep and seizures localize the seizure-onset zone in focal epilepsy.Epilepsia · 2023Article
- Prevalence and localization of nocturnal epileptiform discharges in mild cognitive impairment.Brain communications · 2023Article
- Sleep and epilepsy: A snapshot of knowledge and future research lines.Journal of sleep research · 2022Review
- Sleep-wake states change the interictal localization of candidate epileptic source generators.Sleep · 2022Article
- Untangling a Web: Basic Mechanisms of the Complex Interactions Between Sleep, Circadian Rhythms, and Epilepsy.Epilepsy currents · 2021Article
- Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy.Journal of neural engineering · 2020Article
- Local Sleep Slow-Wave Activity Colocalizes With the Ictal Symptomatogenic Zone in a Patient With Reflex Epilepsy: A High-Density EEG Study.Frontiers in systems neuroscience · 2020Article
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7 authors.
Funding
Abstract
In this study, we applied high-density EEG recordings (HD-EEG) to quantitatively characterize the fine-grained spatiotemporal distribution of inter-ictal epileptiform discharges (IEDs) across different sleep stages. We quantified differences in spatial extent and duration of IEDs at the scalp and cortical levels using HD-EEG source-localization, during non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep, in six medication-refractory focal epilepsy patients during epilepsy monitoring unit admission. Statistical analyses were performed at single subject level and group level across different sleep stages for duration and distribution of IEDs. Tests were corrected for multiple comparisons across all channels and time points. Compared to NREM sleep, IEDs during REM sleep were of significantly shorter duration and spatially more restricted. Compared to NREM sleep, IEDs location in REM sleep also showed a higher concordance with electrographic ictal onset zone from scalp EEG recording. This study supports the localizing value of REM IEDs over NREM IEDs and suggests that HD-EEG may be of clinical utility in epilepsy surgery work-up.
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