ArticleScientific reports2020
Divergent genes encoding the putative receptors for growth hormone and prolactin in sea lamprey display distinct patterns of expression.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- A Cftr-independent, Ano1-rich seawater-adaptive ionocyte in sea lamprey gills.The Journal of experimental biology · 2025Article
- Endocrine control of gill ionocyte function in euryhaline fishes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis.Frontiers in immunology · 2024Article
- Discovery of prolactin-like in lamprey: Role in osmoregulation and new insight into the evolution of the growth hormone/prolactin family.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Roles of leptin in initiation of acquired growth hormone resistance and control of metabolism in rainbow trout.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- The crucial role of prolactin-lactogenic hormone in Covid-19.Molecular and cellular biochemistry · 2022Review
- The Origination of Growth Hormone/Insulin-Like Growth Factor System: A Story From Ancient Basal Chordate Amphioxus.Frontiers in endocrinology · 2022Review
- Rapid genetic adaptation to recently colonized environments is driven by genes underlying life history traits.BMC genomics · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
Growth hormone receptor (GHR) and prolactin receptor (PRLR) in jawed vertebrates were thought to arise after the divergence of gnathostomes from a basal vertebrate. In this study we have identified two genes encoding putative GHR and PRLR in sea lamprey (Petromyzon marinus) and Arctic lamprey (Lethenteron camtschaticum), extant members of one of the oldest vertebrate groups, agnathans. Phylogenetic analysis revealed that lamprey GHR and PRLR cluster at the base of gnathostome GHR and PRLR clades, respectively. This indicates that distinct GHR and PRLR arose prior to the emergence of the lamprey branch of agnathans. In the sea lamprey, GHR and PRLR displayed a differential but overlapping pattern of expression; GHR had high expression in liver and heart tissues, whereas PRLR was expressed highly in the brain and moderately in osmoregulatory tissues. Branchial PRLR mRNA levels were significantly elevated by stage 5 of metamorphosis and remained elevated through stage 7, whereas levels of GHR mRNA were only elevated in the final stage (7). Branchial expression of GHR increased following seawater (SW) exposure of juveniles, but expression of PRLR was not significantly altered. The results indicate that GHR and PRLR may both participate in metamorphosis and that GHR may mediate SW acclimation.
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