Evidence map›Paper›PMID 32015385›Full record

ArticleScientific reports2020

Enhanced effect of recombinant human soluble thrombomodulin by ultrasound irradiation in acute liver failure.

Kota Hoshino, Yoshihiko Nakamura, Takafumi Nakano, Akiko Watanabe, Hong Sheng, Katsuro Tachibana, Hiroyasu Ishikura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Hepatoprotective and antioxidant effects ofInternational journal of biochemistry and molecular biology · 2025
    Article
  2. Thrombomodulin Improves Cognitive Deficits in Heat-Stressed Mice.The international journal of neuropsychopharmacology · 2024
    Article
  3. Article
  4. Aging · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kota HoshinoDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Yoshihiko NakamuraDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.ORCID http://orcid.org/0000-0002-2297-2885
Takafumi NakanoDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.ORCID http://orcid.org/0000-0001-5667-1979
Akiko WatanabeDepartment of Anatomy, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Hong ShengDepartment of Anatomy, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Katsuro TachibanaDepartment of Anatomy, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. k-tachi@fukuoka-u.ac.jp.
Hiroyasu IshikuraDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Fukuoka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The administration of recombinant human soluble thrombomodulin (rhsTM) significantly improves liver inflammation and increases the survival rate of patients with acute liver failure (ALF). However, rhsTM is dose-dependently correlated to the risk of bleeding. Recently, ultrasound (US) was found to enhance the effect of various drugs. Thus, the present study aimed to determine the enhancement effect of US irradiation on rhsTM in ALF. rhsTM (1 mg/kg) and US (1 MHz, 0.3 W/cm

Indexed as

Alanine TransaminaseAnimalsAspartate AminotransferasesDisease Models, AnimalHMGB1 ProteinHumansLiverLiver Failure, AcuteMaleMiceThrombomodulinTreatment OutcomeTumor Necrosis Factor-alphaUltrasonography, InterventionalAlanine TransaminaseAspartate AminotransferasesHMGB1 ProteinThrombomodulinTumor Necrosis Factor-alpha

Identifiers

PMID32015385
PMCPMC6997189
OpenAlexW3004873235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.