ArticleScientific reports2020
Serum C-reactive protein is a useful marker to exclude anastomotic leakage after colorectal surgery.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of the significance of neutrophil to lymphocyte ratio in anastomotic leak after gastrointestinal surgeries.BMC surgery · 2024Pooled it
- C-reactive protein can predict anastomotic leak in colorectal surgery: a systematic review and meta-analysis.International journal of colorectal disease · 2021Pooled it
- Clinical Burden of Anastomotic Leak After Elective Colorectal Cancer Surgery: A Multicenter Cohort Study.Journal of clinical medicine · 2026Article
- Stage-wise variation in serum C-reactive protein and cardiovascular risk in chronic kidney disease of uncertain etiology among Sri Lankans; a preliminary study.BMC research notes · 2026Article
- Safe discharge on the second postoperative day after major colorectal surgery: a decision-making strategy based on quantitative serological data.Techniques in coloproctology · 2026Article
- Understanding Anastomotic Healing in Colo-Rectal Surgery; a Multicentric 5-Year Analysis of Predictive Factors for Integrity and Fistula Formation.Diagnostics (Basel, Switzerland) · 2026Article
- Trend of C-Reactive protein after colorectal surgery may increase predictive value of anastomotic leak: a prospective analysis.BMC surgery · 2026Article
- The Clinical Presentation of Anastomotic Leakage Compared Between CRS-HIPEC and Conventional Colorectal Surgery.Annals of surgical oncology · 2026Article
- Complete prevention of anastomotic leakage using total enteric flow diversion.World journal of gastrointestinal surgery · 2025Article
- Preoperative TNF-α predicts uneventful postoperative outcomes in patients undergoing colorectal cancer surgery.Scientific reports · 2025Observational
- Early prediction of anastomotic leakage after rectal cancer surgery: Onodera prognostic nutritional index combined with inflammation-related biomarkers.World journal of gastrointestinal surgery · 2025Article
- The optimal cut-off value of postoperative day three C-reactive protein to predict for major complications in colorectal cancer patients.Langenbeck's archives of surgery · 2025Article
- Article
- Serum nutritional predictive biomarkers and risk assessment for anastomotic leakage after laparoscopic surgery in rectal cancer patients.World journal of gastrointestinal surgery · 2024Article
- Article
- The Value of Systemic Inflammatory Indices for Predicting Early Postoperative Complications in Colorectal Cancer.Medicina (Kaunas, Lithuania) · 2024Article
- Early Detection and Monitoring of Anastomotic Leaks via Naked Eye-Readable, Non-Electronic Macromolecular Network Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Procalcitonin and C-reactive protein as early markers of anastomotic leakage in intestinal resections for advanced ovarian cancer (EDMOCS).Acta obstetricia et gynecologica Scandinavica · 2024Observational
- The value of C-reactive protein, leucocytes and vital signs in detecting major complications after oncological colorectal surgery.Langenbeck's archives of surgery · 2024Article
- Causes and predictors of unplanned reoperations within 30 days post laparoscopic pancreaticoduodenectomy: a comprehensive analysis.Frontiers in oncology · 2024Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Anastomotic leakage is a complication of colorectal surgery. C-reactive protein (CRP) is an acute-phase marker that can indicate surgical complications. We determined whether serum CRP levels in patients who had undergone colorectal surgery can be used to exclude the presence of anastomotic leakage and allow safe early discharge. We included 90 patients who underwent colorectal surgery with primary anastomosis. Serum CRP levels were measured retrospectively on postoperative days (PODs) 1 - 7. Patients with anastomotic leakage (n = 11) were compared to those without leakage (n = 79). We statistically analysed data and plotted receiver operating characteristic curves. The incidence of anastomotic leakage was 12.2%. Diagnoses were made on PODs 3 - 24. The overall mortality rate was 3.3% (18.2% in the leakage group, 1.3% in the non-leakage group; P < 0.045). CRP levels were most accurate on POD 4, with a cutoff level of 180 mg/L, showing an area under the curve of 0.821 and a negative predictive value of 97.2%. Lower CRP levels after POD 2 and levels <180 mg/L on POD 4 may indicate the absence of anastomotic leakage and may allow safe discharge of patients who had undergone colorectal surgery with primary anastomosis.
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