ArticleNature communications2020
Genomic regions under selection in the feralization of the dingoes.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 135 citations in OpenAlex.
- A Test of the Adaptive Lag Hypothesis of the Evolution of Cancer Suppression and Lifespan in Dog Breeds.Genes · 2026Article
- The impacts of European arrival on Australian dingoes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Saltations of cis-regulatory modules in Canidae and Hominidae.Scientific reports · 2025Article
- Kazakh Tobet dogs in the genomic landscape: refining the history of livestock guardian breeds.BMC biology · 2025Article
- Genetic and Anatomical Determinants of Olfaction in Dogs and Wild Canids.Molecular biology and evolution · 2025Article
- Genetic structure and common ancestry expose the dingo-dog hybrid myth.Evolution letters · 2025Article
- Diverse human dimensions affect the management of public and animal health impacts of free-roaming dogs in Australia: a One Health solution.Frontiers in veterinary science · 2025Review
- A comparison of wild boar and domestic pig microbiota does not reveal a loss of microbial species but an increase in alpha diversity and opportunistic genera in domestic pigs.Microbiology spectrum · 2024Article
- Genomic variation, environmental adaptation, and feralization in ramie, an ancient fiber crop.Plant communications · 2024Article
- Selection against domestication alleles in introduced rabbit populations.Nature ecology & evolution · 2024Article
- Ancient genomes reveal over two thousand years of dingo population structure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genomic Consequences of Isolation and Inbreeding in an Island Dingo Population.Genome biology and evolution · 2024Article
- Genomic consequences of isolation and inbreeding in an island dingo population.bioRxiv : the preprint server for biology · 2024Article
- Japanese wolves are most closely related to dogs and share DNA with East Eurasian dogs.Nature communications · 2024Article
- selscan 2.0: scanning for sweeps in unphased data.Bioinformatics (Oxford, England) · 2024Article
- Impact of feralization on evolutionary trajectories in the genomes of feral cat island populations.PloS one · 2024Article
- Genomic signatures of bottleneck and founder effects in dingoes.Ecology and evolution · 2023Article
- Genome-wide variant analyses reveal new patterns of admixture and population structure in Australian dingoes.Molecular ecology · 2023Article
- Origin and population structure of native dog breeds in the Korean peninsula and East Asia.iScience · 2023Article
- Assessing Genomic Diversity and Signatures of Selection in Chinese Red Steppe Cattle Using High-Density SNP Array.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dingoes are wild canids living in Australia, originating from domestic dogs. They have lived isolated from both the wild and the domestic ancestor, making them a unique model for studying feralization. Here, we sequence the genomes of 10 dingoes and 2 New Guinea Singing Dogs. Phylogenetic and demographic analyses show that dingoes originate from dogs in southern East Asia, which migrated via Island Southeast Asia to reach Australia around 8300 years ago, and subsequently diverged into a genetically distinct population. Selection analysis identifies 50 positively selected genes enriched in digestion and metabolism, indicating a diet change during feralization of dingoes. Thirteen of these genes have shifted allele frequencies compared to dogs but not compared to wolves. Functional assays show that an A-to-G mutation in ARHGEF7 decreases the endogenous expression, suggesting behavioral adaptations related to the transitions in environment. Our results indicate that the feralization of the dingo induced positive selection on genomic regions correlated to neurodevelopment, metabolism and reproduction, in adaptation to a wild environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.