Evidence map›Paper›PMID 32015143›Full record

ArticleJournal of bacteriology2020

Genetic and Biochemical Analysis of CodY-Mediated Cell Aggregation in Staphylococcus aureus Reveals an Interaction between Extracellular DNA and Polysaccharide in the Extracellular Matrix.

Kevin D Mlynek, Logan L Bulock, Carl J Stone, Luke J Curran, Marat R Sadykov, Kenneth W Bayles, Shaun R Brinsmade

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
0.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

  1. The metabolic trap:Journal of medical microbiology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Pathogens (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Beyond the double helix: the multifaceted landscape of extracellular DNA inFrontiers in cellular and infection microbiology · 2024
    Review
  12. How Do Phages Disrupt the Structure ofInternational journal of molecular sciences · 2023
    Article
  13. Article
  14. Article
  15. Infection and immunity · 2023
    Article
  16. Review
  17. A Review of Biofilm Formation ofAntibiotics (Basel, Switzerland) · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kevin D MlynekDepartment of Biology, Georgetown University, Washington, DC, USA.
Logan L BulockDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Carl J StoneDepartment of Biology, Georgetown University, Washington, DC, USA.
Luke J CurranDepartment of Biology, Georgetown University, Washington, DC, USA.
Marat R SadykovDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Kenneth W BaylesDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Shaun R BrinsmadeDepartment of Biology, Georgetown University, Washington, DC, USA shaun.brinsmade@georgetown.edu.ORCID 0000-0002-5381-2817
Georgetown University · USUniversity of Nebraska Medical Center · US

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2009 to 2023
$32.1M
Nutritional regulation of pathogenesis in Staphylococcus aureusR01AI137403 · NIAID · GEORGETOWN UNIVERSITY · PI BRINSMADE, SHAUN R · 2018 to 2022
$2.2M
The molecular control of bacterial programmed cell deathR01AI125589 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAYLES, KENNETH W. · 2016 to 2020
$1.9M
Role of branched-chain fatty acids in physiology and virulence of Staphylococcus aureusR56AI137403 · NIAID · GEORGETOWN UNIVERSITY · PI BRINSMADE, SHAUN R · 2024 to 2024
$481k
Role of amino acids and GTP in Staphylococcus aureus pathogenesisR21AI123708 · NIAID · GEORGETOWN UNIVERSITY · PI BRINSMADE, SHAUN R · 2017 to 2018
$428k
NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125589NIAID NIH HHS R01 AI137403NIAID NIH HHS R21 AI123708NIAID NIH HHS R56 AI137403
6 · The paper itself

Abstract

The global regulator CodY links nutrient availability to the regulation of virulence factor gene expression in

Indexed as

BiofilmsBacterial ProteinsDNA, BacterialExtracellular MatrixGene Expression Regulation, BacterialHumansPolysaccharides, BacterialRepressor ProteinsStaphylococcal InfectionsStaphylococcus aureusBacterial ProteinsCodY protein, Staphylococcus aureusDNA, Bacterialpolysaccharide intercellular adhesinPolysaccharides, BacterialRepressor ProteinsbiofilmCodYeDNAexopolysaccharidelipoproteinsPIAStaphylococcus aureus

Identifiers

PMID32015143
PMCPMC7099133
OpenAlexW3003976136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.