Evidence map›Paper›PMID 32015138›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release.

Erica Tagliatti, Oscar D Bello, Philipe R F Mendonça, Dimitrios Kotzadimitriou, Elizabeth Nicholson, Jeff Coleman, Yulia Timofeeva, James E Rothman, Shyam S Krishnakumar, Kirill E Volynski

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Article
  3. Synaptotagmin-1 serves as a primary ZnNature communications · 2025
    Article
  4. Article
  5. Article
  6. Article
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  9. Article
  10. Brain-derived neurotrophic factor scales presynaptic calcium transients to modulate excitatory neurotransmission.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Article
  13. c.1103T>C (p.Ile368Th) de novo Variant in Synaptotagmin 1 (International medical case reports journal · 2024
    Article
  14. Article
  15. The Core Complex of the CaJournal of molecular biology · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Erica TagliattiDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
Oscar D BelloDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
Philipe R F MendonçaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
Dimitrios KotzadimitriouDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
Elizabeth NicholsonDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
Jeff ColemanDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
Yulia TimofeevaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom.
James E RothmanDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; james.rothman@yale.edu s.krishnakumar@ucl.ac.uk k.volynski@ucl.ac.uk.
Shyam S KrishnakumarDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; james.rothman@yale.edu s.krishnakumar@ucl.ac.uk k.volynski@ucl.ac.uk.ORCID 0000-0001-6148-3251
Kirill E VolynskiDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; james.rothman@yale.edu s.krishnakumar@ucl.ac.uk k.volynski@ucl.ac.uk.
Yale University · USNational Hospital for Neurology and Neurosurgery · GBUniversity of Warwick · GB

Funding

Medical Research Council MC_UP_1502/1Medical Research Council MR/M013812/1Medical Research Council MR/T002786/1Wellcome Trust
6 · The paper itself

Abstract

Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca

Indexed as

AnimalsExocytosisMiceMice, KnockoutMutation, MissenseNeurotransmitter AgentsSynapsesSynaptic TransmissionSynaptotagmin INeurotransmitter AgentsSynaptotagmin IC2B domainfusion clampsynaptic transmissionsynaptotagmin

Identifiers

PMID32015138
PMCPMC7035618
OpenAlexW3004157527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.