Evidence map›Paper›PMID 32015129›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Kv2.1 channels play opposing roles in regulating membrane potential, Ca

Samantha C O'Dwyer, Stephanie Palacio, Collin Matsumoto, Laura Guarina, Nicholas R Klug, Sendoa Tajada, Barbara Rosati, David McKinnon, James S Trimmer, L Fernando Santana

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Uncovering a Sex-Specific cAMP Landscape in Vascular Smooth Muscle.bioRxiv : the preprint server for biology · 2026
    Article
  2. CaThe Journal of physiology · 2026
    Article
  3. Review
  4. Amyloid β alters vascular CaThe Journal of physiology · 2025
    Article
  5. Sexually dimorphic mechanisms of HJournal of applied physiology (Bethesda, Md. : 1985) · 2025
    Article
  6. α1Journal of the American Heart Association · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. The formation of KCommunications biology · 2023
    Article
  14. Article
  15. NPC1-dependent alterations in KNature communications · 2023
    Article
  16. The formation of KResearch square · 2023
    Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samantha C O'DwyerDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
Stephanie PalacioDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
Collin MatsumotoDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
Laura GuarinaDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
Nicholas R KlugDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
Sendoa TajadaDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
Barbara RosatiDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
David McKinnonDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
James S TrimmerDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.
L Fernando SantanaDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616; lfsantana@ucdavis.edu.ORCID 0000-0002-4297-8029

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
NFAT-induced Regional Variations in Kv4 Channel Expression in HeartR01HL085686 · NHLBI · UNIVERSITY OF WASHINGTON · PI SANTANA, LUIS F · 2007 to 2020
$5.7M
Multi-Scale Modeling of Vascular Signaling UnitsR01HL152681 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2020 to 2023
$2.4M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Tuning L-Type Ca Channel Activity in Arterial Smooth Muscle by Kv Channel-Mediated ClusteringR01HL144071 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANTANA, LUIS F, TRIMMER, JAMES S · 2018 to 2021
$2.0M
NHLBI NIH HHS R01 HL085686NHLBI NIH HHS R01 HL144071NHLBI NIH HHS R01 HL152681NHLBI NIH HHS T32 HL086350NIGMS NIH HHS T32 GM099608NIH HHS OT2 OD026580
6 · The paper itself

Abstract

The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K

Indexed as

AnimalsArteriesCalciumCalcium Channels, L-TypeCells, CulturedFemaleMaleMembrane PotentialsMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleShab Potassium ChannelsCACNA1C protein, mouseCalciumCalcium Channels, L-TypeKcnb1 protein, mouseShab Potassium Channelscalcium channel clusteringvoltage-gated calcium channelsvoltage-gated potassium channels

Identifiers

PMID32015129
PMCPMC7035623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.