Evidence map›Paper›PMID 32015105›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Activation of mosquito immunity blocks the development of transmission-stage filarial nematodes.

Elizabeth B Edgerton, Abigail R McCrea, Corbett T Berry, Jenny Y Kwok, Letitia K Thompson, Brittany Watson, Elizabeth M Fuller, Thomas J Nolan, James B Lok, Michael Povelones

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  4. Genome-Wide Inference of Essential Genes inInternational journal of molecular sciences · 2025
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  7. Review
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  9. bioRxiv : the preprint server for biology · 2023
    Article
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  12. Editorial: Unconventional animal models in infectious disease research, volume II.Frontiers in cellular and infection microbiology · 2023
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Elizabeth B EdgertonDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Abigail R McCreaDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Corbett T BerryDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Jenny Y KwokDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Letitia K ThompsonDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Brittany WatsonDepartment of Clinical Sciences & Advanced Medicine, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Elizabeth M FullerShelter Medicine, Charleston Animal Society, North Charleston, SC 29406.
Thomas J NolanDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
James B LokDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104.
Michael PovelonesDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104; mpove@vet.upenn.edu.ORCID 0000-0002-3766-2097
University of Pennsylvania · US

Funding

INSULIN-LIKE SIGNALING IN PARASITIC NEMATODE DEVELOPMENTR01AI050668 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2002 to 2023
$7.1M
Targeting mosquito complement to alter the specificity of the innate immune responseR01AI139060 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI POVELONES, MICHAEL JOSEPH · 2018 to 2022
$2.0M
Short-term Training: students in health professional schoolsT35OD010919 · OD · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2012 to 2026
$1.8M
NIAID NIH HHS R01 AI050668NIAID NIH HHS R01 AI139060NIH HHS T35 OD010919
6 · The paper itself

Abstract

Mosquito-borne helminth infections are responsible for a significant worldwide disease burden in both humans and animals. Accordingly, development of novel strategies to reduce disease transmission by targeting these pathogens in the vector are of paramount importance. We found that a strain of

Indexed as

AedesAnimalsDirofilaria immitisInsect ProteinsLarvaMosquito VectorsInsect ProteinsBrugiaDirofilariaimmunityMalpighian tubulemosquito

Identifiers

PMID32015105
PMCPMC7035481
OpenAlexW3004128078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.