Evidence map›Paper›PMID 32015101›Full record

ArticleMolecular and cellular biology2020

Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells.

Pavlo Lazarchuk, John Hernandez-Villanueva, Maria N Pavlova, Alexander Federation, Michael MacCoss, Julia M Sidorova

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

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  16. miR-548d-3p Alters Parasite Growth and Inflammation inFrontiers in cellular and infection microbiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Pavlo LazarchukUniversity of Washington, Department of Pathology, Seattle, Washington, USA.
John Hernandez-VillanuevaUniversity of Washington, Department of Pathology, Seattle, Washington, USA.
Maria N PavlovaUniversity of Washington, Department of Pathology, Seattle, Washington, USA.
Alexander FederationAltius Institute for Biomedical Sciences, Seattle, Washington, USA.
Michael MacCossUniversity of Washington, Department of Genome Sciences, Seattle, Washington, USA.
Julia M SidorovaUniversity of Washington, Department of Pathology, Seattle, Washington, USA julias@uw.edu.
University of Washington · USAltius Institute for Biomedical Sciences · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Su-In Lee · 1995 to 2026
$27.1M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
Epigenetics of replication stress in human cellsR01GM115482 · NIGMS · UNIVERSITY OF WASHINGTON · PI SIDOROVA, JULIA · 2016 to 2020
$1.6M
Systematic and Comprehensive Sampling of Peptides in Mixtures by Tandem Mass SpectrometryR21CA192983 · NCI · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2015 to 2017
$648k
NCI NIH HHS P30 CA015704NCI NIH HHS R21 CA192983NIA NIH HHS P30 AG013280NIGMS NIH HHS P41 GM103533NIGMS NIH HHS R01 GM115482
6 · The paper itself

Abstract

Newly synthesized histone H4 that is incorporated into chromatin during DNA replication is acetylated on lysines 5 and 12. Histone deacetylase 1 (HDAC1) and HDAC2 are responsible for reducing H4 acetylation as chromatin matures. Using CRISPR-Cas9-generated

Indexed as

AcetylationATPases Associated with Diverse Cellular ActivitiesCell LineChromatinDNADNA-Binding ProteinsDNA ReplicationHistone Deacetylase 1Histone Deacetylase 2HistonesHumansLysineProtein Processing, Post-TranslationalATAD2 protein, humanATPases Associated with Diverse Cellular ActivitiesChromatinDNADNA-Binding ProteinsHDAC1 protein, humanHDAC2 protein, humanHistone Deacetylase 1Histone Deacetylase 2HistonesLysinechromatinDNA replicationhistone acetylationhistone deacetylaseRNA-DNA hybridtranscription

Identifiers

PMID32015101
PMCPMC7156220
OpenAlexW3004297888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.